Die Dynamik des menschlichen Kreislaufes unter der Wirkung von Kreislaufmitteln

Böger, Andreas; Deppe, B.; Wezler, K.

doi:10.1007/bf01861208

Cited by 38 publications

(3 citation statements)

References 10 publications

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“…The systolic pressure fell more than the diastolic in every instance except Number 18. In all but 5 instances (Numbers 4, 5, 8,11, and 17) the diastolic pressure was maintained at 60 mm. Hg or above, and frequently it did not fall below its control value (Numbers 1, 2, 3, 10, and 12).…”

Section: Effects Of Anesthesia On Arterial Blood Pressurementioning

confidence: 93%

“…Insofar as increased capillary volume results from arteriolar dilatation it can only affect this picture by exaggerating these changes. Opposed to the tendency of arteriolar dilatation to lower the systolic pressure will be any increase in cardiac output which may result from increased venous pressure, and it is conceivable that with moderate dilatation this pressor factor could nearly balance the depressor factors, so that the systolic pressure would be well maintained.8 8 Perhaps the best examples of arteriolar dilatation are afforded by the action of adrenin and ephedrine,…”

Section: Effects Of Anesthesia On Arterial Blood Pressurementioning

confidence: 99%

“…Even excluding the possible effects of the surgical excitation of vasodilator fibers, and of anes- 8 In anesthetized animals small doses of adrenin cause a fall in arterial pressure, a phenomenon not observed in unanesthetized animals (22) thetics, there remains the question to what extent the delicate pattern of the vasomotor system and the set of the presumptively autonomous peripheral vasomotor apparatus are caused to depart from normal by the procedures of opening the abdomen and fingering the viscera whereby they may suffer some local excitation, if not traumatic injury, by handling, drying, and chilling.…”

Section: Effects Of Anesthesia On Arterial Blood Pressurementioning

confidence: 99%

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Effects of Spinal Anesthesia on Circulation in Normal Unoperated Man, with Reference to Autonomy of Arterioles and Especially Those of Renal Circulation.

Smith¹,

Rovenstine²,

Goldring³

et al. 1940

Anesthesia & Analgesia

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The present study, comprising observations on 21 subjects given high spinal anesthesia, is an investigation of the effects of anesthetic denervation in normal man, uncomplicated by surgical intervention, on the circulation with particular reference to the vascular bed of the kidney. It is concluded that the renal arterioles are distinctly autonomous, in the sense that under basal conditions the renal vascular tone is not affected by anesthetic denervation. Our observations further suggest that the arteriolar bed generally (apart from the skin) possesses considerably more autonomy than is usually attributed to it-sufficient, in fact, in the normal supine individual at rest, to maintain an essentially normal arterial pressure. We find no evidence of significant arteriolar dilatation during high spinal anesthesia, such reduction in blood pressure as occurs being attributable, we believe, to diminished circulating blood volume in consequence of dilatation of the capillaries, venules, and veins.Part I deals with the following topics: (1) Methods; (2) the effects of spinal anesthesia on renal blood flow; (3) on the arterial pressure, and (4) on the reflex responses to posture, hypercapnia, and anoxemia. Part II consists of a review of the evidence on (5) the existence of tonic vasoconstrictor activity and on (6) the existence of autonomy in the peripheral arterioles generally, and (7) in the kidney in particular, and (8) the peripheral effects of hypercapnia and anoxemia. In (5) it is brought out that the notion of tonic vasoconstrictor activity in the sympathetic nervQus system, apart from the skin, is based largely upon animal experiments which are seriously complicated by general anesthesia, venous dilatation, etc., and that the information so obtained cannot be transferred with confidence to normal animals, and certainly not to man.PART I MethodsThe subjects were male convalescent patients ranging in age from 18 to 50 years who, with a single exception, presented no abnormal signs contraindicating selection for this study. They were examined in the morning in the basal, fasting condition, and were prepared for the measurement of renal blood flow and filtration rate by the clearance method, as described by Smith, Goldring, and Chasis (93). In the earlier observations the phenol red and inulin (35) clearances were followed, but after the introduction of the diodrast clearance (93), all three clearances were used. The phenol red clearance serves as a check on the diodrast clearance, the constancy of the phenol red/diodrast clearance ratio before and after anesthesia demonstrating that procaine per se has no effect upon the tubular excretory mechanism. The infusions corresponded to the typical infusion cited by Chasis, Ranges, Goldring, and Smith (18). Zero time was taken as the beginning of the priming infusion, which occupied about 10 minutes; the infusion was then changed to the sustaining infusion, the first urine collection period being started at about 30 minutes. The sustaining infusion was usually interrupted ...

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Section: Effects Of Anesthesia On Arterial Blood Pressurementioning

confidence: 93%

Section: Effects Of Anesthesia On Arterial Blood Pressurementioning

confidence: 99%