Die elektroenzephalographisch bestimmte sedierende Wirkung (Vigilosomnographie) des neuen Thienodiazepin-Derivates Clotiazepam (Trecalmo^®)

Recent advances in the clinical pharmacology of benzodiazepines part II: Pharmacodynamics

“…Even after administration of extremely high single doses of daytime tranquillizers, such as 75mg and 150mg prazepam, we could not observe a significant increase in delta activity . Sedative effects may already be seen by visual evaluation, as was demonstrated by Aufdembrinke et al (1981) utilizing vigilosomnography, and Mak et al (1982). The latter authors studied flunitrazepam, diazepam, chlordiazepoxide and clorazepate, and observed after flunitrazepam injections an increase of beta activity but also of high diffuse slow delta waves, which was accompanied by sleep, while successive doses of diazepam, chlordiazepoxide or chlorazepate caused this delta activity to disappear with the patient awakening.…”