Die Epicutantestung

Bandmann, Hans‐Jürgen; Dohn, W

doi:10.1007/978-3-642-49783-4

Cited by 95 publications

(7 citation statements)

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“…Thus benzocaine 22/100 is far more intimately related with PPD 15/22/100 than with procaine 2/22/100. This is rather astonishing if one compares their structural chemical formulas [8].…”

Section: Discussionmentioning

confidence: 99%

“…and so is sulfanilamide 5/100 (of which 4/5/100 reacted to PPD) and sulfathiazol 4/100 (of which 2/4/100 reacted to PPD). It is less well known that benzocaine 22/100 often cross-reacts with the so-called para-substituted substances [8], such as PPD: 15/22/100. PPD and its close relatives presum ably will have played the role of inciting agents and not the benzocaine, because in the Netherlands it still is an unusual remedy for leg ulcers (it is still in use for burns and as a constituent of suppositories, however.)…”

Section: Discussionmentioning

confidence: 99%

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Contact Allergic Investigations in 100 Patients with Ulcus Cruris

Malten

Kuiper

Staak³

1973

Dermatology

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The incidence of contact-allergic reactions to some 10 substances out of 75 tested in 100 selected leg-ulcer patients is about 5 times as high as in eczematous patients. These substances are p-phenylenediamine, p-aminoazobenzene, Pellidol®, benzocaine, diaminodiphenylmethane, neomycin, coal tar, balsam of Peru, wool alcohols. Sesame oil was the tenth substance. It is used to clean the skin from rests of ointments. In Holland it figures as a constituent of the often-used, so-called pasta zinci oleosa, ung. diachylon, ung. simplex, and of emulgide cream. In our opinion, not only topical medicaments should be regarded as frequent contact sensitizers in leg-ulcer patients. A second class of important sensitizers in this group of patients appears to be the para-substituted substances such as p-phenylenediamine (and azo dyes) as inducers considered to be responsible for the cross-reaction of drugs such as benzocaine and sulfanilamide, and of the rubber additive, diaminodiphenylmethane. Stress is laid upon five preventive measures concerning contactants in leg-ulcer patients (stockings, bandages, topical medications) and upon the desirability of having non-sensitizing preservatives and stabilizers at one’s disposal–especially for topical medications in leg-ulcer patients who apparently are sensitized with greater ease than patients with other skin ailments.

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“…Thus benzocaine 22/100 is far more intimately related with PPD 15/22/100 than with procaine 2/22/100. This is rather astonishing if one compares their structural chemical formulas [8].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Contact Allergic Investigations in 100 Patients with Ulcus Cruris

Malten

Kuiper

Staak³

1973

Dermatology

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“…In the diagnosis and prevention of allergic contact eczema, it is often of value to look for certain common sensitizers with simple chemical methods. Such methods are described for formaldehyde (Blohm 1959), cobalt (Feigl 1958), nickel (Fisher 1973), chromate (FeigI1958), parabens (Bandmann & Dohn 1967), p-phenylenediamine (Fregert 1972) and primin (Agrup et al 1968).…”

mentioning

confidence: 99%

Simple methods for demonstration of epoxy resins of bisphenol A type

Fregert

Trulsson

1978

Contact Dermatitis

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Low molecular weight oligomers of epoxy resins of bisphenol A type are common sensitizers. For demonstrating the presence of sensitizing oligomers of these resins, two simple methods are described. The first one, a colour reaction, demonstrates the presence of the bisphenol A skeleton. If this test is positive, thin-layer chromatography is carried out to demonstrate the presence of low molecular weight oligomers of epoxy resins. Some practical applications are reported.

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“…Contact dermatitis caused by witch hazel (hamamelis) is reported in the older literature (3)(4)(5). Though recommendations for patch testing have been given (6,7), no allergic reactions to witch hazel have to my knowledge been reported until recently (2). Reactions to cucumber extracts have not been reported.…”

Section: Discussionmentioning

confidence: 99%