2011
DOI: 10.1002/ange.201107639
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Die ersten Strukturen von 7‐Helix‐Transmembranproteinen in Lösung

Abstract: Herausforderung gemeistert: Die Strukturaufklärung des 7‐Helix‐Transmembranproteins Proteorhodopsin in Lösung gelang kürzlich mithilfe NMR‐spektroskopischer Methoden auf der Basis von klassischen NOEs in Kombination mit paramagnetischen Relaxationverstärkungen (PREs) und dipolaren Restkopplungen (RDCs) (siehe Bild). Die Ergebnisse bedeuten einen großen Fortschritt für die Strukturbiologie.

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“…The ideal basis for the rational design of peptidomimetics is of course the knowledge of the receptor‐bound neuropeptide conformation. Unfortunately, this remains a challenge because neuropeptides bind to membrane‐bound G protein‐coupled receptors, which are notoriously difficult to crystallize 8,9. In fact, there have been no reports describing the conformation of a receptor‐bound insect neuropeptide.…”
Section: Introductionmentioning
confidence: 99%
“…The ideal basis for the rational design of peptidomimetics is of course the knowledge of the receptor‐bound neuropeptide conformation. Unfortunately, this remains a challenge because neuropeptides bind to membrane‐bound G protein‐coupled receptors, which are notoriously difficult to crystallize 8,9. In fact, there have been no reports describing the conformation of a receptor‐bound insect neuropeptide.…”
Section: Introductionmentioning
confidence: 99%