Die Expression des Chemokin-Rezeptors CCR7 in kolorektalen Karzinomen korreliert mit deren Lymphknotenmetastasierung

Hepatic lymphatic vascular system in health and disease

“…As mentioned above, CCL21 in LECs recruits CCR7-expressing DCs toward lymphatic vessels and facilitates their egression from the liver [83]. However, CCR7 is also expressed by a variety of malignant tumors, and the CCL21-CCR7 axis is considered as one of the causal factors for lymph node metastasis [84][85][86][87][88][89]. A positive correlation between expression levels of CCR7 and lymph node metastasis was reported in HCC patients [90].…”