Die Haarmelanogenese bei der Endoxan-Alopecie und deren Beeinflussung durch Corticosteroide

A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

“…These are particularly prominent and clinically highly relevant in the course of chemotherapy-induced alopecia (CIA). Decades ago, different types of alopecias as well as some key parameters for the recognition of defined stages of chemotherapy-induced hair follicle dystrophy in mammals were defined (Braun-Falco and Theisen, 1959;Braun-Falco, 1961Zaun, 1964;Herzberg, 1966;Kostanecki et al, 1966;Homan et al, 1968). For nearly 40 y, these publications have been the only references for the classification of hair follicle dystrophy, although none of them offers a comprehensive, unified classification scheme for use in the laboratory.…”

A Murine Model for Inducing and Manipulating Hair Follicle Regression (Catagen): Effects of Dexamethasone and Cyclosporin A

“…In some of those 17-20% anagen VI follicles that were still visible in DEX-treated skin on days 15 and 16 postdepilation (Fig 3, upper panels), the width of the proximal hair bulb was slightly narrower than in vehicle-treated anagen VI follicles, mainly in follicles from the flank regions, A'rfninor degree of melanin clumping and irregular distribution of melanin granules was found in about 1% of DEX-induced catagen and telogen follicles, similar to though much less pronounced than the pigmentation disorder seen with cyclophosphamide-induced alopecia in mice [19] and humans [3,23], Cutaneous thinning in both the epidermal and the dermal compartment was observed histologically in the skin of DEX-treated mice, but not in vehicle controls, as is to be expected from the prolonged administration of a very potent glucocorticosteroid to the skin [24,25], …”

Hair pigmentation disorders or 50 years of German‐Polish alliance for study on a severe side effect of chemotherapy: Kostanecki's legacy

“…With these advances in our understanding of chemotherapy‐induced alopecia, it is often forgotten that the pigmentary manifestations of chemotherapy‐induced hair follicle dystrophy and subsequent alopecia were for the first time described in detail by Wojciech Kostanecki , a Polish dermatologist working in the 1960s and 1970s, both in his homeland, and in Germany. His observations lead him to pass his professorial qualifying exam ‘Habilitation’ in 1970.…”

“…His observations lead him to pass his professorial qualifying exam ‘Habilitation’ in 1970. Kostanecki published several papers in Archiv für klinische und experimentelle Dermatologie, two of which concerned chemotherapy‐induced hair pigmentation disorders: the first reported the observations of human chemotherapy‐induced alopecia, and the second was devoted to a suitable mouse model . This parallel approach to dissect the problem at hand was crucial and exemplary, because it generated translationally relevant research by combing the advantages of the murine model with observations of human hair follicles .…”