In combination with high-resolution ultrasound (US), vacuum-assisted biopsy (VB) is a patient friendly, outpatient diagnostic procedure with the potential for curative resection of selected lesions and thus represents a valuable supplement to microbiopsy procedures already established. The indication spectrum for US-guided VB is still under discussion. The Minimally Invasive Breast Procedures Study Group (AG MiMi) of the German Senology Society gives recommendations for indications, the investigators' qualifications, technical requirements, documentation, quality assurance and follow up intervals necessary for the procedure. These consensus recommendations consolidate the recommendations for experts in this field and have not been formulated as guidelines. Results from further studies must support and, where necessary, supplement the recommendations made so far.Keywords Ultrasound-assisted vacuum breast biopsy .