Die Heredität der Psychosen

Jolly, Ph.

doi:10.1007/978-3-662-26210-8

Cited by 11 publications

(43 citation statements)

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“…The questionnaires were sent back to me, almost all filled out more or less well. In general, their usefulness exceeded my expectations (Jolly, 1913a, pp. 380–381).…”

Section: Literature Reviewmentioning

confidence: 82%

“…Of course, it was my aim to compile a material that is as large as possible, to prevent any one‐sidedness. I also did not exclude, as is often done in such research, paresis and other predominantly exogenous mental disturbances, instead I included all mental disturbances without exceptions (Jolly, 1913a, p. 379).…”

Section: Literature Reviewmentioning

confidence: 99%

“…He then discusses which classes of relatives should be examined in such a study, and in particular whether to include “collaterals” (which Jolly defined as “uncles, aunts, great‐uncles, great‐aunts, and cousins of both genders”) and whether to study both the “ascendants” (or ancestors) and the “descendants.” Jolly concludes he should study all relatives for whom high quality clinical information was available:

In my research I have endeavored, without keeping to a particular schema, to obtain indications about as many of the relatives of the mentally ill as I could … I have intentionally only used such cases where extensive clinical histories are available (Jolly, 1913a, p. 382).…”

Section: Literature Reviewmentioning

confidence: 99%

“…He emphasizes two key points. First,

If one can thus assume that a larger or a smaller part of the mental illnesses or rather, the predisposition to these, is hereditary, the type of heredity and furthermore, what is actually being inherited, is yet an unresolved question (Jolly, 1913a, p. 378).…”

Section: Introductionmentioning

confidence: 99%

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Philipp Jolly and his 1913 “the heredity of psychosis”: Homogeneity versus heterogeneity of familial transmission and an early look at Mendelian models for manic‐depressive illness and dementia praecox

Kendler

Klee²

2021

American J of Med Genetics Pt B

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Philipp Jolly's 1913 extensive monograph “The Heredity of Psychoses” provides, in both his detailed literature review and new pedigree study, an extensive assessment of a key issue in the psychiatric genetics of his day: the degree to which the familial transmission of psychiatric disorders was specific (or homogeneous) versus nonspecific (or heterogeneous). Contrary to a number of earlier observations, Jolly concludes that heterogeneous transmission is rare. Multiple psychiatric disorders can occur in one family because members of a family may have elevated predispositions to more than one disorder rather than one predisposition which increases risk for a wide range of conditions. A notable exception to this, he notes, is within manic‐depressive illness (MDI), where different forms of illness run together within families. Jolly is also among the earliest investigators to evaluate simple Mendelian models for MDI and dementia praecox (DP). While his methods were primitive and contained only “eye‐ball” examinations rather than statistical modeling, Jolly demonstrated considerable conceptual sophistication in the early application of such models. He concludes that DP is likely a recessive disorder. MDI, he states, is either a recessive condition or demonstrates “gender‐based dominant heredity” where heterozygote females are affected, and heterozygote males are not.

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“…The questionnaires were sent back to me, almost all filled out more or less well. In general, their usefulness exceeded my expectations (Jolly, 1913a, pp. 380–381).…”

Section: Literature Reviewmentioning

confidence: 82%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

“…He emphasizes two key points. First,

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Philipp Jolly and his 1913 “the heredity of psychosis”: Homogeneity versus heterogeneity of familial transmission and an early look at Mendelian models for manic‐depressive illness and dementia praecox

Kendler

Klee²

2021

American J of Med Genetics Pt B

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“…These papers were published on a cusp in the history of psychiatric genetics. Planning was already starting in the application of Mendelian models to psychiatric illness in the US and Germany that would be published in the next decade (Jolly, 1913; Rosanoff & Orr, 1911; Rudin, 1916; Rüdin, 1911). This would result in a shift from the hereditary burden model of Koller and Diem to a focus on rates of illness in different classes of relatives.…”

Section: Discussionmentioning

confidence: 99%

Julius Wagner von Jauregg, Otto Diem and research methods for assessing the contributions of hereditary burden to mental illness risk: 1902–1906

Kendler

Klee²

2021

American J of Med Genetics Pt B

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After decades of methodological stasis in 19th century psychiatric genetics, when uncontrolled studies reported high rates of hereditary burden in hospitalized patients, Koller completed the first controlled study in 1895. We pick up this narrative 7 years later when the well‐known Julius Wagner v. Jauregg published a biting critique of the then current psychiatric genetics' literature. In 1905, partially in response to Wagner v. Jauregg, Otto Diem attempted to replicate and extend Koller's study. Wagner v. Jauregg then wrote a follow‐up to his earlier critique in 1906, commenting on Diem's investigation. Themes discussed in this point‐counterpoint included the necessity of statistical methods to draw meaningful conclusions about the impact of hereditary burden on mental illness, the required sample size and proper selection of controls, the classes of relatives which should optimally be studied, the problems of obtaining accurate information on familial illnesses, the nature of the disorders in families which contribute to mental illness risk and the common unquestioned dogmatic belief that insanity is very often due to hereditary causes. Both Wagner v. Jauregg and Diem spoke out forcefully against the common assumption that hereditary burden operated in a deterministic fashion and emphasized the need to consider other causes of illness.

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Die Anlagen der Charaktere

Kronfeld

1925

Psychotherapie

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Die Heredität der Psychosen

Cited by 11 publications

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Philipp Jolly and his 1913 “the heredity of psychosis”: Homogeneity versus heterogeneity of familial transmission and an early look at Mendelian models for manic‐depressive illness and dementia praecox

Philipp Jolly and his 1913 “the heredity of psychosis”: Homogeneity versus heterogeneity of familial transmission and an early look at Mendelian models for manic‐depressive illness and dementia praecox

Julius Wagner von Jauregg, Otto Diem and research methods for assessing the contributions of hereditary burden to mental illness risk: 1902–1906

Die Anlagen der Charaktere

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