Die induzierbare laryngeale Obstruktion (ILO) – Ursachen, klinische Präsentation, Diagnostik und Therapie

Dillenhöfer, Stefanie; Hinrichs, Bernd; Kohl, A.; Kuhnigk, M.; Maas, R.; Pfeiffer-Kascha, D.; Rutt, Th.; Schlegtendal, Anne; Seidenberg, J.; Spindler, Thomas; Suerbaum, C.; Wilmsmeyer, Brigitte; Zeidler, Susanne; Koerner-Rettberg, Cordula

doi:10.1007/s00112-021-01159-z

Cited by 2 publications

(1 citation statement)

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“…The data reported here are in concordance with the published literature and support the evidence that long-term sequelae after SARS-CoV-2 infection in children are rare. Some authors have suggested a possible link to dysfunctional breathing (for example inducible laryngeal obstruction) after SARS-CoV-2 infection (36), a condition that is well known to occur after other (infectious) triggers (53). Further studies are needed to elucidate this possible pathological link.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Function and Persistent Clinical Symptoms in Children and Their Parents 12 Months After Mild SARS-CoV-2 Infection

Bode

Haendly²,

Fabricius³

et al. 2022

Front. Pediatr.

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BackgroundPulmonary involvement is the leading cause of morbidity and mortality after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Long-term impairment has been reported in adults with severe infection. However, most infections cause only mild symptoms or are even asymptomatic, especially in children. There is insufficient evidence regarding pulmonary outcome measures in mild SARS-CoV-2. The objectives of this study were to determine spirometry parameters after SARS-CoV-2 infection and correlate those with reported persisting symptoms in children, adolescents, and adults.MethodsData on clinical symptoms during acute infection as well as SARS-CoV-2 serology results were recorded. Twelve months after infection, spirometry was performed and information on persisting symptoms was collected using a structured questionnaire. 182 participants (108 SARS-CoV-2 positive) from 48 families were included; 53 children (< 14 years), 34 adolescents and young adults (14–25 years), and 95 adults.ResultsSpirometry values did not significantly differ between the particular subgroups of the cohort (adults, adolescents, children; infected and non-infected individuals). Adults reported more symptoms during acute infection as well more persisting fatigue (29.7% of participants), reduced physical resilience (34.4%), and dyspnea (25.0%) 12 months after infection than adolescents (fatigue 26.7%, reduced physical resilience 20%, and 0% dyspnea) and children (4%, 0%, 0%, respectively). There was no correlation between persistent subjective symptoms and spirometry results.DiscussionChildren and adolescents are less affected than adults by acute SARS-CoV-2 as well as by post-infection persistent symptoms. Spirometry was not able to demonstrate any differences between healthy individuals and participants who had suffered from mild SARS-CoV-2 12 months after the infection.

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Section: Discussionmentioning

confidence: 99%