Die interdisziplinäre Therapie von Ependymomen im Kindesalter

Abstract

At present the cooperating clinicians are optimizing treatment procedures to improve results and to reduce toxicity. In radiotherapy reduction of target volume to the involved field for all non-disseminated ependymomas as well as the introduction of hyperfractionated schedules and conformal therapy with dose escalation are important developments.

Current and Future Strategies in Radiotherapy of Childhood Low-Grade Glioma of the Brain

“…Today, prospective trials in childhood brain tumors are indispensable to assess the role of radiotherapy both in terms of survival and late effects [43,59,72]. Based on these experiences, the following aims will be addressed in the future SIOP LGG 2003 radiotherapy protocol: a) utilizing modern treatment techniques to reduce the integral radiation dose given to normal tissue compared with the previous protocol; b) to record and monitor the integral dose to tumor and normal tissue as a basis for future assessment of late effects and quality of life of long-term survivors (see part II); c) to assess response of tumor and clinical symptoms to radiotherapy; d) to assess the pattern of relapse when using modern treatment techniques; e) to assess the role of craniospinal irradiation in children with disseminated low-grade glioma (phase II trial).…”

Ependymoma in Adults: Surgery, Reoperation and Radiotherapy for Survival

“…Recently, location and radical excision seem to be also important prognostic factors [12][13][14]. For postoperative patient management, histological grading should be only of importance [15][16][17].…”

Current and Future Strategies in Radiotherapy of Childhood Low-Grade Glioma of the Brain

“…Chemotherapy has been investigated in recent years in younger children in order to postpone the necessity of irradiation, because of an increased risk of severe late effects. However, data on late effects in the literature are difficult to interpret, and the impact on the selection of treatment modality with respect to age, prognostic factors and risk factors to develop late effects is largely unknown [39,59,70].…”