Die kindliche Osteomyelitis

Jansson, Annette; Jansson, Volkmar; Liebe, Alessandro von

doi:10.1007/s00132-008-1402-6

Cited by 18 publications

(16 citation statements)

References 28 publications

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“…It is believed that the etiological pathogens of infection in osteomyelitis (including hematogenous one) are a number of heterogeneous populations and types of bacteria, which suggests that a possible invasion is determined not by generic and species pathogenicity but by disorders in local homeostasis, immunity, microcirculation [34]. So, in the metaphyseal part of long tubular bones at the place of transition of the arterial flow to the venous one, the laminar blood flow it is changed into the turbulent one, which creates favorable conditions for local microbial invasion [35]. A further determining factor in the invasion is a relative depletion of phagocytic cells and the inferiority of the endothelial lining in these parts of the vascular bed, which allows bacteria to invariably translocate into the surrounding tissue [36].…”

Section: Pathomorphology Of the Infection Process In Bone Tissuementioning

confidence: 99%

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Chronic post-traumatic osteomyelitis as a problem of contemporary traumatology and orthopedics (literature review)

Mironov¹,

Tsiskarashvili²,

Gorbatiuk³

2019

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The paper discusses the problem of chronic osteomyelitis from the positions that are either circumvented or not taken into account by practitioners. Microbiological, clinical, pharmacological, pathomorphological and pathophysiological aspects of the inflammatory process of bone tissue are presented. The review also outlines the immunological features of the chronic osteomyelitis course, as well as a contemporary view on this disease as an interdisciplinary problem.

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Section: Pathomorphology Of the Infection Process In Bone Tissuementioning

confidence: 99%

“…Fig. 2 Molecular factors of S.aureus involved in interaction with osteoblasts [35]. The pathogen protein A directly binds to the TNFR-1 receptor of osteoblasts thus activating a cascade of cell reactions that result in apoptosis.…”

Section: Pathomorphology Of the Infection Process In Bone Tissuementioning

confidence: 99%

Chronic post-traumatic osteomyelitis as a problem of contemporary traumatology and orthopedics (literature review)

Mironov¹,

Tsiskarashvili²,

Gorbatiuk³

2019

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“…The pathogenesis of this process has been theoretically described. Inoculation of the metaphyseal vessels occurs at the transition point from the arteriolar vessels to the venous sinusoids, slowing blood flow and increasing vascular turbulence (Jansson et al, 2009). These sites of turbulence may be predisposed to bacterial infection by providing an opportunity for local invasion (Fig.…”

Section: Acute Haematogenous Osteomyelitismentioning

confidence: 99%

Pathophysiology and Pathogenesis of Osteomyelitis

Roy¹,

Somerson²,

Kerr³

et al. 2012

Osteomyelitis

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“…The pathophysiology behind this is the inoculation of metaphyseal vessels at the transition point of arteriolar vessels to the venous sinusoids slowing down the blood flow and increasing the vascular turbulence [3]. Osteomyelitis is mainly divided into 3 types: Acute, subacute and chronic type.…”

Section: Introductionmentioning

confidence: 99%

Study of Osteomyelitis in paediatric patients

Sindhur¹,

Razak²,

Ks³

et al. 2017

Int J Pediatr Res

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Introduction: Osteomyelitis is defined as inflammation of bone. Though the main culprits are bacteria occasionally fungi may also be involved. Prognosis of untreated or delayed treatment onset osteomyelitis is often bad and leads to adverse outcomes. Very few cases of osteomyelitis are reported from India as compared to other infectious conditions. In this study we aim to study the number of patients, male: female ratio, type of osteomyelitis and the bacterial profile associated with osteomyelitis. Methods: After obtaining Institutional Ethics approval, the present study was conducted from 1 st January 2016-31 st December 2016 at KVG Medical College, Sullia. Blood and sample like fluid aspirate or discharge collected was subjected to microscopy and culture. Antibiotic susceptibility testing was done using disk diffusion methods. Radiological data of the patients was also collected. Results: Bacteria were isolated from 32 cases. The most affected age group was of 6-10 years of age (46.87%). Males were more affected as compared to females and male: female ratio was 3:1. Maximum number of patients were of acute osteomyelitis (87.5%) followed by subacute osteomyelitis (9.38%) and chronic osteomyelitis was found in just a single patient (3.12%). Long bones like tibia (56.25%), femur (18.75%), humerus (12.5%) were mostly affected. Blood culture was positive in 65.62% cases. Methicillin Sensitive Staphylococcus Aureus (MSSA) was the most common isolate (56.25%) followed by, Methicillin Resistant Staphylococcus Aureus (MRSA), Acinetobacter, Coagulase Negative Staphylococcus (CONS), Streptococcus pyogens, E.coli and Pseudomonas. Conclusion: Thus, S. aureus was the most common cause of acute bacterial osteomyelitis and mostly affected school age group children.

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Die kindliche Osteomyelitis

Cited by 18 publications

References 28 publications

Chronic post-traumatic osteomyelitis as a problem of contemporary traumatology and orthopedics (literature review)

Chronic post-traumatic osteomyelitis as a problem of contemporary traumatology and orthopedics (literature review)

Pathophysiology and Pathogenesis of Osteomyelitis

Study of Osteomyelitis in paediatric patients

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