Die Koazervation und ihre Bedeutung für die Biologie

Jong, H. G. Bungenberg de

doi:10.1007/bf01610198

Cited by 144 publications

(22 citation statements)

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“…When oppositely-charged polyelectrolyte solutions are mixed, a liquid-liquid phase separation occurs that is called “complex coacervation” [1,2,3]. Complex coacervates, polymer-rich domains, show good hydrophilicity due to significantly large amount of water inside the domain, and low interfacial tension [4,5].…”

Section: Introductionmentioning

confidence: 99%

Effect of Ionic Group on the Complex Coacervate Core Micelle Structure

et al. 2019

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Pairs of ionic group dependence of the structure of a complex coacervate core micelle (C3M) in an aqueous solution was investigated using DLS, cryo-TEM, and SANS with a contrast matching technique and a detailed model analysis. Block copolyelectrolytes were prepared by introducing an ionic group (i.e., ammonium, guanidinium, carboxylate, and sulfonate) to poly(ethylene oxide-b-allyl glycidyl ether) (NPEO = 227 and NPAGE = 52), and C3Ms were formed by simple mixing of two oppositely-charged block copolyelectrolyte solutions with the exactly same degree of polymerization. All four C3Ms are spherical with narrow distribution of micelle dimension, and the cores are significantly swollen by water, resulting in relatively low brush density of PEO chains on the core surface. With the pair of strong polyelectrolytes, core radius and aggregation number increases, which reflects that the formation of complex coacervates are significantly sensitive to the pairs of ionic groups rather than simple charge pairing.

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Section: Introductionmentioning

confidence: 99%

Effect of Ionic Group on the Complex Coacervate Core Micelle Structure

et al. 2019

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“…Coacervation is a liquid/liquid phase separation (LLPS) phenomenon in aqueous solution caused by the complexation of dissolved polymers in the aqueous solution due to a variety of attractive forces [1,2,3,4]. When an aqueous solution is adjusted to a specific pH and ionic strength at which solvated polymers attract each other, the polymer chains mingle, partially desolvate, and recruit other polymer chains to form dynamic dense polymer droplets within the fluid [1,5]. This dense dynamic polymer droplet is called a coacervate, originating from the Latin word coacervatus, which means “cluster”.…”

Section: Introductionmentioning

confidence: 99%

“…The variety of attractive forces for coacervation could be electrostatic bonds, hydrogen bonds, cation-π interactions, hydrophobic interactions, and other attractive van der Waals forces in aqueous solution [6,7,8,9]. A coacervate was first reported by the Dutch scientists Bungenberg de Jong and Kruyt as an LLPS resulting from mixing two oppositely charged polyelectrolytes, a positively charged gelatin and a negatively charged gum Arabic [1].…”

Section: Introductionmentioning

confidence: 99%

Upper Critical Solution Temperature (UCST) Behavior of Coacervate of Cationic Protamine and Multivalent Anions

et al. 2019

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Complex coacervation is an emerging liquid/liquid phase separation (LLPS) phenomenon that behaves as a membrane-less organelle in living cells. Yet while one of the critical factors for complex coacervation is temperature, little analysis and research has been devoted to the temperature effect on complex coacervation. Here, we performed a complex coacervation of cationic protamine and multivalent anions (citrate and tripolyphosphate (TPP)). Both mixtures (i.e., protamine/citrate and protamine/TPP) underwent coacervation in an aqueous solution, while a mixture of protamine and sodium chloride did not. Interestingly, the complex coacervation of protamine and multivalent anions showed upper critical solution temperature (UCST) behavior, and the coacervation of protamine and multivalent anions was reversible with solution temperature changes. The large asymmetry in molecular weight between positively charged protamine (~4 kDa) and the multivalent anions (<0.4 kDa) and strong electrostatic interactions between positively charged guanidine residues in protamine and multivalent anions were likely to contribute to UCST behavior in this coacervation system.

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“…The cell membrane must be primarily treated as a physical boundary surface as far as the surface tension is effective to hold its shape (7), although a precipitation membrane or a denatured membrane will occur by its changed conditions. As was described above, it is obvious that the hi-spherical cleavage surface may be a good evidence for the surface tension.…”

Section: Discussionmentioning

confidence: 99%

Physical Analysis of the Mechanism of Cell Division in Sea-Urchin Eggs

Hirota¹

1953

Publ. SMBL

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Die Koazervation und ihre Bedeutung für die Biologie

Cited by 144 publications

References 0 publications

Effect of Ionic Group on the Complex Coacervate Core Micelle Structure

Effect of Ionic Group on the Complex Coacervate Core Micelle Structure

Upper Critical Solution Temperature (UCST) Behavior of Coacervate of Cationic Protamine and Multivalent Anions

Physical Analysis of the Mechanism of Cell Division in Sea-Urchin Eggs

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