Die Konzentration der Carnitinfraktionen im III. Trimenon der Schwangerschaft in Abhängigkeit von der Glukosetoleranz

Hh, Günter; Peulecke, W; Oehler, K.; Scharf, A.; Schumann, Gunter; Sohn, C

doi:10.1055/s-2002-39655

Zentralbl Gynakol

2002

DOI: 10.1055/s-2002-39655

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Die Konzentration der Carnitinfraktionen im III. Trimenon der Schwangerschaft in Abhängigkeit von der Glukosetoleranz

Günter Hh

W Peulecke²,

K. Oehler³

et al.

Abstract: Due to the high overlap of results, carnitine isn 't suitable for further differentiation of glucose metabolism or to evaluate the efficacy of therapy in non insulin dependent GDM.

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Cited by 3 publications

References 17 publications

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Carnitine status of pregnant women: effect of carnitine supplementation and correlation between iron status and plasma carnitine concentration

et al. 2009

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Background/Objectives: It has been shown that plasma carnitine concentrations markedly decline during gestation in women. The reason for this, however, is unknown. One objective of this study was to investigate the effect of carnitine supplementation on plasma carnitine concentrations in pregnant women. The second objective was to investigate the hypothesis that reduced plasma carnitine concentrations during gestation are caused by a reduced carnitine synthesis because of a diminished iron status. Subjects/Methods: Healthy pregnant women (n ¼ 26) were randomly assigned in two groups receiving either a L-carnitine supplement (500 mg L-carnitine per day as L-carnitine L-tartrate) (n ¼ 13) or placebo (n ¼ 13) from the 13th week of gestation to term. Results: In the control group, there was a marked reduction of plasma carnitine concentration from the 12th week of gestation to term. This reduction was prevented by the supplementation of carnitine. In the control group, there was a positive relationship between the parameters of iron status (mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and ferritin) and plasma concentration of carnitine (Po0.05). Moreover, there were inverse correlations between the concentrations of ferritin and the carnitine precursor g-butyrobetaine in plasma, and between g-butyrobetaine and carnitine in plasma (Po0.05).Conclusions: This study confirms that plasma carnitine concentrations decline in the course of pregnancy, an effect that can be prevented by the supplementation of carnitine. Data of this study, moreover, suggest that the decline of plasma carnitine concentration during pregnancy could be caused by a reduced rate of carnitine biosynthesis, possibly because of an inadequate iron status.

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Carnitine status of pregnant women: effect of carnitine supplementation and correlation between iron status and plasma carnitine concentration

et al. 2009

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Gestational diabetes exhibits lack of carnitine deficiency despite relatively low carnitine levels and alterations in ketogenesis

Pappa

Anagnou

Salamalekis

et al. 2005

The Journal of Maternal-Fetal & Neonatal Medicine

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Serum acylcarnitines levels as a potential predictor for gestational diabetes: a systematic review and meta-analysis

Luo

Zhu

2023

Front. Public Health

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AimsGestational diabetes mellitus (GDM) stands as a prevalent obstetric complication bearing consequential health implications for both mother and child. While existing studies have probed the alterations in acylcarnitines during GDM, an updated systematic meta-analysis is needed to consolidate these findings. Hence, this study endeavours to furnish a comprehensive systematic review and meta-analysis delineating the association between acylcarnitines and GDM, aimed at bolstering diagnostic accuracy and preventive measures against GDM.MethodsTo extract pertinent studies for this meta-analysis, we meticulously scoured databases such as PubMed, Web of Science, Embase, and Cochrane Library up until May 2023. The inclusion criteria were studies contrasting plasma metabolomics between two cohorts: women diagnosed with GDM and normoglycemic pregnant women. Weighted mean differences (SMDs) and 95% confidence intervals (CIs) were calculated using random-effects models. The I2 index was employed to quantify heterogeneity amongst the studies. All meta-analyses were executed using Stata version 12.0.ResultsOur meta-analysis included eight studies encompassing 878 pregnant women. The analysis disclosed that relative to normoglycemic pregnant women, women with GDM exhibited significantly elevated levels of Short-Chain Acylcarnitines (SCAC) (SMD: 0.19, 95% CI: 0.02–0.36, I2 = 71.3%). No substantial difference was discerned in fasting total carnitine levels (SMD: 0.15, 95% CI: −0.16–0.31, I2 = 68.2%), medium-chain acylcarnitines (MCAC) (SMD: 0.08, 95% CI: −0.02–0.36, I2 = 79.0%), and long-chain acylcarnitines (LCAC) (SMD: 0.04, 95% CI: −0.06–0.15, I2 = 0%). Neither funnel plot assessment nor Egger’s regression and Begg’s rank correlation tests indicated any evidence of publication bias.ConclusionOur meta-analysis suggests that elevated levels of SCAC may heighten the risk of GDM onset. Given GDM’s deleterious impact on pregnant women and their offspring, these findings underscore the clinical imperative of managing this condition. Early surveillance of plasma metabolomic profiles, particularly serum acylcarnitine concentrations, may equip clinicians with a valuable tool for timely diagnosis and intervention in GDM.

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Die Konzentration der Carnitinfraktionen im III. Trimenon der Schwangerschaft in Abhängigkeit von der Glukosetoleranz

Abstract: Due to the high overlap of results, carnitine isn 't suitable for further differentiation of glucose metabolism or to evaluate the efficacy of therapy in non insulin dependent GDM.

Cited by 3 publications

References 17 publications

Carnitine status of pregnant women: effect of carnitine supplementation and correlation between iron status and plasma carnitine concentration

Carnitine status of pregnant women: effect of carnitine supplementation and correlation between iron status and plasma carnitine concentration

Gestational diabetes exhibits lack of carnitine deficiency despite relatively low carnitine levels and alterations in ketogenesis

Serum acylcarnitines levels as a potential predictor for gestational diabetes: a systematic review and meta-analysis

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