1991
DOI: 10.1002/ange.19911031008
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Die Medizinische Chemie im Goldenen Zeitalter der Biologie: Lehren aus der Steroid‐ und Peptidforschung

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Cited by 58 publications
(9 citation statements)
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“…The wealth of pharmaceuticals available today has largely been fueled by a detailed understanding of molecules within biological systems. [1][2][3] As a result, the majority of the widely used medicaments were originally identified on the basis of a toxic effect or through design towards a specific molecular target (for example, a key protein in a cascade). [4][5][6][7] Can this most successful concept be extended?…”
Section: Introductionmentioning
confidence: 99%
“…The wealth of pharmaceuticals available today has largely been fueled by a detailed understanding of molecules within biological systems. [1][2][3] As a result, the majority of the widely used medicaments were originally identified on the basis of a toxic effect or through design towards a specific molecular target (for example, a key protein in a cascade). [4][5][6][7] Can this most successful concept be extended?…”
Section: Introductionmentioning
confidence: 99%
“…Particularly in the interaction of peptides with proteins the various types of &turns (for a classification, see Venkatachalam, 1968; Rose et al, 1985) have frequently been found to be involved, be it for binding peptide immunogens to antibodies (Stanfield et al, 1990; Rini et al, 1992; Scherf et al, 1992) or for binding peptide hormones to receptors (Buku et al, 1987;Nachmann et al, 1991). Because of compactness, &turns are thought to be important structural elements for constructing peptide mimetics (Veber, 1981; Hirschmann, 1991).…”
mentioning
confidence: 99%
“…[9] Despite intense investigation by the scientific community, there is still a need for new synthetic methods for novel peptides or simplified and more stable peptidomimetics. [10] In particular, cyclic amides incorporating heterocyclic units other than oxazole or thiazole moieties, which are biosynthetically derived from the functionalized amino acids serine, threonine, or cysteine, should afford interesting compounds with new properties. To the best of our knowledge, no cyclic amides containing thiophene units are found in Nature, which is the key feature of the current study.…”
Section: Introductionmentioning
confidence: 99%