Die Metastasenabsiedlung in die Nasennebenhöhlen: Fallmitteilung und Literaturübersicht1

Abstract

The case of an 87-year old man with widespread prostatic cancer is reported. During the autopsy macroscopically visible metastases were found within the frontal sinuses. These tumor masses destroyed the posterior osseous wall of the frontal sinus and formed polypoid bulging masses. In contrast to the macroscopically unaffected mucous membrane of the sphenoid sinus the maceration specimen of the skull base demonstrated a spongious-mossy, osteoplastic metastasis, lining the sphenoid sinus like a tapestry. This affection started from an exhaustive osteoplastic metastasis within the clivus. No metastases could be found in both antrums or the ethmoids. Retrospectively no symptoms from the paranasal sinuses could be eruated, only occasional pain of the frontal bone. The review of the world literature with 123 reports revealed 169 cases. Renal cell carcinomas most frequently metastasize into the paranasal sinuses (67 cases), followed by bronchogenic carcinomas (15 cases). Thyroid cancers and cancers of the mammary gland are responsible for 13 respectively 14 cases. The prostate also adds 12 cases. The paranasal sinuses are affected in diminishing frequency: maxillary sinus (55 cases), sphenoid sinus (37 cases), ethmoidal cells (23 cases) and frontal sinus (15 cases). In 38 cases exhaustive metastases affecting two or more paranasal sinuses are reported. The statement of literature, that metastases affecting the paranasal sinuses are much more frequent than reported, cannot be supported by our study, because the intensive autoptic investigation of 50 skulls of patients suffering from widespread cancers revealed no further cases of metastatic processes of the paranasal sinuses.

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

“…Two cases presented simultaneously in the paranasal sinus and the bony orbit [63, 69]. Clinical manifestations include epistaxis, nasal obstruction, visual disturbances, and facial or intraoral swelling [70, 71]. The maxillary sinus is the most commonly involved sinus followed by the sphenoid sinus, ethmoid, and frontal sinus [70, 72].…”

Metastatic Renal Cell Carcinoma of the Nasal Septum: A Case Report

“…The mass can be identified as metastatic after histopathological examination of the tissue sample. Malignancies metastasizing to the sinonasal region include, in the order of frequency, RCC, bronchogenic carcinoma, thyroid and breast carcinomas, and prostate tumors (2). Of these metastatic masses, tumors originating from intrapelvic organs are significant due to their ability to paradoxically spread to the head and neck region.…”

“…While malignant lesions are rare tumors, metastatic masses are highly rare in this group. To name in the order of frequency, renal cell carcinoma (RCC), bronchogenic carcinoma, thyroid and breast carcinomas, prostate tumors can metastasize to the sinonasal region (2). Particularly RCC is the most common metastatic tumor of this region (3).…”

Sinonasal Carcinoma: Updated Phenotypic and Molecular Characterization

“…A review of 169 cases carcinoma metastasized tothe paranasal sinuses [29,38] revealed that most primary tumors were located in the kidney (40%), followed by the lung, breast, thyroid, and prostate (approximately 10% at each site). The maxillary sinuses were the most commonly affected site, followed by the sphenoid sinuses, the ethmoid sinuses, and the frontal sinuses; in 22% of the cases, multiple sinuses were involved [29,38].…”