Die Muskelfaserkonstante und das Wachstumsgesetz der menschlichen Herzkammern

Linzbach, A. J.

doi:10.1007/bf00947940

Cited by 77 publications

(18 citation statements)

References 37 publications

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“…The documentation that conditions of overload, aging, and ischemic heart disease do not alter the relative proportion of the various myocyte populations 130 strongly suggests that the demonstrations of myocyte cellular hyperplasia obtained initially by Linzbach 45,60 and subsequently by other investigators 50,124 -130 are valid. Additionally, mononucleated cells represent 3/4 of the myocytes of the human heart, differing significantly from other mammals, such as mice, 68 rats, 64 and dogs.…”

Section: Heart Failurementioning

confidence: 87%

“…19,43 However, the cellular changes taking place in the human heart have not been carefully defined. There is no information on myocyte volume at birth in the 2 ventricles, although the claim has been made that myocyte diameter is comparable shortly after birth in the left and right sides of the heart 44,45 but that later in life left ventricular myocytes are slightly larger than right ventricular myocytes. 46,47 The total number of ventricular myocytes at birth is Ϸ1ϫ10 9 , 48,49 but this parameter is extremely variable.…”

Section: Postnatal Myocardial Growthmentioning

confidence: 99%

“…45,60 The critical heart weight theory introduced by this author in the late 1940s and early 1950s has suggested that, in the presence of a cardiac weight of Ն500 g, myocyte proliferation begins and that this cellular process constitutes the prevailing mechanism of additional growth of the heart. 116 These findings were restricted to the left ventricle, but subsequent observations have demonstrated that a similar response occurs in the right ventricle.…”

Section: Heart Failurementioning

confidence: 99%

See 2 more Smart Citations

Ventricular Myocytes Are Not Terminally Differentiated in the Adult Mammalian Heart

Anversa

Kajstura

1998

Circulation Research

335

177

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Section: Heart Failurementioning

confidence: 87%

Section: Postnatal Myocardial Growthmentioning

confidence: 99%

Section: Heart Failurementioning

confidence: 99%

See 1 more Smart Citation

Ventricular Myocytes Are Not Terminally Differentiated in the Adult Mammalian Heart

Anversa

Kajstura

1998

Circulation Research

335

177

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“…These data indicate a harmonic, proportional length-to-width growth of myocytes which was postulated earlier. 10 Taking into consideration the Poisson distribution of muscle cell diameters, the total number of muscle cells was calculated as…”

Section: Methodsmentioning

confidence: 99%

“…In previous reports on cellular dimensions in both cardiac and skeletal muscles, the diameters of muscle cells were measured in histological cross-sections, assuming a cylindrical model of the cells. 10 The diameters either were measured directly in a number of individual myocytes or were estimated indirectly. In the case of direct measurements, a difficulty arises from the fact that the cells are not always cut perpendicularly to their long axis and, therefore, their cross-sections appear to be elipsoid rather than circular.…”

Section: )mentioning

confidence: 99%

The influence of aging and growth on the postnatal development of cardiac muscle in rats.

Rakusan

Raman²,

Layberry

et al. 1978

Circulation Research

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SUMMARY We studied the effects of different rates of postnatal body growth on the growth of rat myocytes. Growth rates were altered by adjusting the number of newborn animals per litter to 4 (fast-growing), 8 (normal), or 16 (slow-growing). On the 21st postnatal day, average left ventricular weights (mg ± SEM) were 80 ± 5 in slowgrowing 131 ± 8 in normal, and 183 ± 5 in fast-growing rats. Average myocyte diameters, obtained from direct microscopic measurements in longitudinal sections prepared from eight animals in each group, were 8.6 ± 0.3, 9.8 ± 0.2, and 10.2 ± 0.3 fim, respectively. The total number and total length of myocytes constituting the left ventricle were estimated, assuming a constant length-to-width ratio and cyclindrical model of myocytes. The estimated total number of myocytes constituting the respective left ventricles were 23.6 ± 2.0, 24.5 ± 2.2, and 31.1 ± 2.1 millions. All differences between experimental groups were significant by analysis of variance. When the estimated total numbers of myocytes and their estimated total lengths were related to the left ventricular weights, a significant linear correlation was obtained, which indicated their dependence on the organ growth and their relative independence of age. These indications were strengthened further by analysis of covariance, which showed that the differences in all morphometric data among the three groups of hearts may be explained entirely by different growth rates of the left ventricle. These results also suggest that the accelerated growth of the heart during the early postnatal period is associated with increased proliferation of myocytes.PROLIFERATION of rat cardiac muscle cells declines rapidly during late embryonic and early postnatal development. Three to four weeks after birth, the total number of cardiac muscle cells is believed to be close to adult values, and further growth of the heart may be accounted for by the growth of the existing cardiac cells.1-1 However, one important question remains to be answered: are the individual cardiac cells "programmed" for a finite number of nuclear and cellular divisions for a given age or can the rate of proliferation previously observed during the early postnatal period be altered by other factors such as organ growth itself? Temporarily dissociating the growth-to-age relationship during the early postnatal period should provide an answer to the above question.The growth rate of the mammalian body is both agedependent and nutrition-dependent. In suckling rats, the number of young animals per litter is a decisive factor, because the source of food is limited to the mother. Thus, by varying the number of young rats per litter, the growth rate can be altered so that the body weight and heart weight may vary 2-4 times between the animals from the small litters (4 rats) and from the large litters (16 rats) when they are weaned at 21 days of age. This approach was used in our present experiments in order to study the effects of slow, normal, and accelerated body and heart growth rate on th...

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Postnatal anatomical and functional development of the heart: A species comparison

Hew

Keller²

2003

Birth Defects Research Pt B

121

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Die Muskelfaserkonstante und das Wachstumsgesetz der menschlichen Herzkammern

Cited by 77 publications

References 37 publications

Ventricular Myocytes Are Not Terminally Differentiated in the Adult Mammalian Heart

Ventricular Myocytes Are Not Terminally Differentiated in the Adult Mammalian Heart

The influence of aging and growth on the postnatal development of cardiac muscle in rats.

Postnatal anatomical and functional development of the heart: A species comparison

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