Die Niere nach Thermonekrose

Helpap, B.; Rodenbusch, U.; Grouls, V.

doi:10.1007/bf00427062

Cited by 4 publications

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References 14 publications

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“…In contrast to cryonecrosis the leucocytic response during the first three days and later on during the reparative phase of woundhealing the lymphocytic responses are much more pronounced. This latter cellreaction might be compatible with the assumption of a possible immunologic reaction after thermonecrosis (see Helpap et al, 1977).…”

Section: Cell-kinetic Sequences In the Woundhealing After Thermonecrosismentioning

confidence: 88%

The wound healing of the liver after thermonecrosis. Autoradiographical investigations with3H-thymidine on rats

1977

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Histological and autoradiographical studies were performed on the liver of rats after local thermonecrosis. The results were compared with those after local cryonecrosis. After thermocoagulation (740 degrees C/4 sec) each animal received an i.p. injection of 3H-TdR (2.5 micronC/1 g body weight). The survival times ranged from 12 hours to 30 days. In the HE stained histological slides the morphological changes and the percentages of the cells in the granulation tissue and in the stripping film autoradiograms the percentages of radioactively labeled fibroblasts and hepatocytes were determined. After 12--24 hours the thermonecrosis is complete with leucocytic demarcations. Five days later widespread granulation tissue develops in the marginal zone of the necrosis. 20 to 30 days after thermocoagulation small necrotic parts are still seen in the center sorrounded by a fibrous scar. Autoradiographically the highest percentages of labeled epithelial and mesenchymal cells are observed between the second and the third postoperative day. Four weeks after thermonecrosis there are still increased cellular proliferative activities. Therefore, it can be stated that the inflammatory resorptive woundhealing processes following thermonecrosis in the liver are maintained much longer than after other physical injuries especially after cryonecrosis.

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Section: Cell-kinetic Sequences In the Woundhealing After Thermonecrosismentioning

confidence: 88%

The wound healing of the liver after thermonecrosis. Autoradiographical investigations with3H-thymidine on rats

1977

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The cellular reaction of the kidney after different physical injuries

Helpap

Grouls

1981

Urol. Res.

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Autoradiographic investigations on kidney cells were performed after focal cryolesions (-180 to -196 degrees C) and focal heat application (740 degrees C). Cells were studied 12 h to 30 days after the lesions had been produced. In the damage granulation tissue the percentage of radioactively labelled fibroblasts as well as the percentage distribution of leucocytes, monocytes, macrophages, lymphocytes, fibroblasts and fibrocytes and the mean cell concentration were determined. There were no significant differences in the leucocytic and monocytic cell reactions after the two types of physical injuries. However, the percentage of fibroblasts, fibrocytes and macrophages was higher and the percentage of lymphocytes lower after cryonecrosis when compared to heat application. The cell concentration increased during the last 2 weeks of the experimental time after a thermolesion. The labelling index of the wound fibroblasts was significantly higher after the 10th day after thermonecrosis than after in sinus freezing. The increased cellular activity 2 to 4 weeks after heat coagulation of the kidney was probably induced by the delayed resorption of the carbonised necrotic tissue. The reduced phagocytic activity of macrophages might have depended on alteration and modification of molecular cell structures which were different after heat application of freezing. The different lymphocytic reaction seems to be the consequence of different immune responses of the lymphatic system. It is suggested that focal thermolesions may have a stimulatory effect on the cell-mediated immune response and that focal cryonecrosis may induce an increase in humoral immune response.

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DNA-synthesis in the rat thymus after focal thermolesions on abdominal organs

Grouls

Helpap

1978

Res. Exp. Med.

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The changes in the DNA-synthesis of lymphocytes in the different zones of the rat thymus were autoradiographically studied with 3H-thymidine after focal thermonecroses (740 degrees C/4 sec) on abdominal organs and sham operation (laparotomy). A single thermolesion was performed in separate groups of rats on the liver and spleen, whereas a third group received multiple heat lesions (liver, kidney, stomach wall). A slight decrease of the labeling index occured during the first 36 h after the sham operation and was attributed to an unspecific stress effect leading to an increased release of corticosterones. The most remarkable and contrasting result was the observation that after thermonecroses a decrease of the labeling index of thymus-lymphocytes did not happen during the first 48 h but rather a marked increased with a maximum on the fifth day. It was concluded that the stimulated DNA-synthesis in the thymus might be related to a cell mediated immune response against thermocoagulated tissue components or to an immediate T-cell dysfunction, which is known to develop after burns. In both cases the thymus might react with an increased division and maturation of lymphocytes regulated through a feed-back mechanism.

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Die Niere nach Thermonekrose

Cited by 4 publications

References 14 publications

The wound healing of the liver after thermonecrosis. Autoradiographical investigations with3H-thymidine on rats

The wound healing of the liver after thermonecrosis. Autoradiographical investigations with3H-thymidine on rats

The cellular reaction of the kidney after different physical injuries

DNA-synthesis in the rat thymus after focal thermolesions on abdominal organs

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