Die Objektivierbarkeit psychopharmakologischer Drogen
am Beispiel von Metylperon

Ambrozi, L.; Birkmayer, W.; Danielczyk, W.

doi:10.1159/000468839

Cited by 7 publications

(2 citation statements)

References 3 publications

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“…In consequence of these and other studies, the compound was tested for tranquillizing properties in man (Ambrozi, Birkmayer & Danielczyk, 1969;Molander & DuvhOk, 1976). It was noted that Melperone prolonged action potential duration (APD) in guinea-pig isolated papillary muscle (Olsson & Arlock, 1976), and it was found to have an antiarrhythmic effect in animals (Petersen, 1978).…”

Section: Introductionmentioning

confidence: 99%

“…The butyrophenone, Melperone, prolonged barbiturate sleeping time in mice, reduced body temperature, and had some analgesic, anticonvulsant and antitremor activity (Christensen, Hernestam, Lassen & Sterner, 1965). In consequence of these and other studies, the compound was tested for tranquillizing properties in man (Ambrozi, Birkmayer & Danielczyk, 1969;Molander & DuvhOk, 1976). It was noted that Melperone prolonged action potential duration (APD) in guinea-pig isolated papillary muscle (Olsson & Arlock, 1976), and it was found to have an antiarrhythmic effect in animals (Petersen, 1978).…”

Section: Introductionmentioning

confidence: 99%

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Differential Actions on Rabbit Nodal, Atrial, Purkinje Cell and Ventricular Potentials of Melperone, a Bradycardic Agent Delaying Repolarization: Effects of Hypoxia

Millar

Williams

1982

British J Pharmacology

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1 Melperone, a butyrophenone tranquillizer, caused bradycardia in vivo and in vitro. 2 Although Melperone had ax-adrenoceptor antagonist activity in the pithed rat, it was not a P-adrenoceptor antagonist, nor was it a cholinoceptor agonist.3 The bradycardic action could be attributed almost entirely to a prolongation by Melperone of action potential duration (APD) in sinus node cells, with little effect on the slow diastolic depolarization. 4 APD was prolonged by Melperone in atrial and ventricular muscle, and most of all in the bundle of His, but only moderately in the terminal Purkinje cells. 5 In all cardiac tissues depolarized by fast inward current, Melperone caused a dose-related reduction in the maximum rate of depolarization and conduction velocity. On desheathed frog nerve Melperone had a local anaesthetic potency equal to that of procaine. 6 There was no negative inotropic effect in cardiac muscle, nor interference with A-V nodal conduction, from which it was inferred that Melperone did not restrict slow inward current. 7 Melperone did not reduce hypoxic shortening of APD relative to the initial value at the start of hypoxia, but because APD was already lengthened by Melperone in normoxic conditions, APD90 during hypoxia remained close to normal values. There was no protection against hypoxic depression of contractions. 8 It was concluded that Melperone had class 1 and class 3 antiarrythmic actions and merited trial as an antiarrhythmic drug.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differential Actions on Rabbit Nodal, Atrial, Purkinje Cell and Ventricular Potentials of Melperone, a Bradycardic Agent Delaying Repolarization: Effects of Hypoxia

Millar

Williams

1982

British J Pharmacology

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Effects of a new butyrophenone derivate (Buronil�) on nocturnal sleep in normal man

Risberg

Henricson

Elmqvist

et al. 1975

Psychopharmacologia

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Nocturnal sleep was studied in eight young normal volunteers (3 female and 5 male students) with polygraphic technique during 2 periods of 10 night each. After 2 adaptation and 2 baseline nights with placebo, they were given methylperone (Buronil) 10 or 50 mg per night during three nights and then again placebo for three withdrawal nights. The study was made double blind. The scoring of the records was done according to the manual by Rechtschaffen and Kales (1968). No changes of sleep stages were seen during the drug periods. The lower dose gave an increase of sleep latency but a decrease of number of awakenings during the night. An increase of REM-periods was shown after 50 mg and also a decrease of REM-latency and REM-density. The only significant change during withdrawal periods was a decrease of REM-sleep after methylperone 50 mg, so there was no "barbiturate type" of withdrawal. The change was also different from that of chloropromazine, which has no clear rebound effect.

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Acute Effects of Oxazepam, Diazepam and Methylperone, alone and in Combination with Alcohol on Sedation, Coordination and Mood

Molander¹,

Duvhök²

1976

Acta Pharmacologica et Toxicologica

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Effects on critical flicker fusion frequency (CFFF), coordination and mood were studied after single oral doses of placebo, alcohol (0.5 ml ethanol/kg b. wt.), oxazepam (10, 20 and 40 mg), diazepam (5, 10, 20 and 40 mg) and methylperone (10, 25 and 50 mg), given either alone, or simultaneously with alcohol or with delayed alcohol administration. Methylperone was found to have a depressant effect similar to or greater (on a weight basis) than that of diazepam and oxazepam respectively. The correlation between sedative and antianxiety effect is discussed. The decrease in CFFF was parallelled by a decreased coordination ability. Alcohol alone had no effect on our parameters, but when given simultaneously with the drugs, it markedly increased the effect of diazepam, while the effect of oxazepam and methylperone were affected to a much lesser degree. The effect of the drugs on psychomotor skills and the interaction between alcohol and the drugs have important implications when treating out‐patients. Methylperone as a potential anti‐anxiety agent is discussed.

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Die Objektivierbarkeit psychopharmakologischer Drogen am Beispiel von Metylperon

Cited by 7 publications

References 3 publications

Differential Actions on Rabbit Nodal, Atrial, Purkinje Cell and Ventricular Potentials of Melperone, a Bradycardic Agent Delaying Repolarization: Effects of Hypoxia

Differential Actions on Rabbit Nodal, Atrial, Purkinje Cell and Ventricular Potentials of Melperone, a Bradycardic Agent Delaying Repolarization: Effects of Hypoxia

Effects of a new butyrophenone derivate (Buronil�) on nocturnal sleep in normal man

Acute Effects of Oxazepam, Diazepam and Methylperone, alone and in Combination with Alcohol on Sedation, Coordination and Mood

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