Die Ökologie und Bedeutung der Proteusgruppe

Tomaschoff, Elisabeth

doi:10.1007/bf01879914

Cited by 7 publications

(6 citation statements)

References 43 publications

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“…Obstructions and other abnormalities of the urinary tract are thought to favour infection with proteus (Tomaschoff, 1969) and other 'atypical' bacteria (de Wardener, 1967;Smallpeice, 1968). Since bacteria of these kinds are characteristic of male infections, even in the absence of obstruction, it is possible that this high frequency in obstructive infections is related more to sex than to obstruction.…”

Section: Methodsmentioning

confidence: 99%

Sex Differences in Childhood Urinary Tract Infection

Bergström¹

1972

Archives of Disease in Childhood

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Bergstrom, T. (1972). Archives of Disease in Childhood, 47, 227. Sex differences in childhood urinary tract infection. Comparison of the clinical picture of nonobstructed urinary tract infection in boys and in girls over the age of 1 year revealed marked differences. The male infections were characterized by a high rate of 'atypical' bacterial aetiology, macroscopical haematuria, and normal temperature, as compared to the female ones. The proportion of patients getting recurrent infections during long-term follow-up was the same in the two sexes. The number of recurrences was, however, higher in the girls than in the boys. Radiological changes similar to postinfectious scar formation were found in 20% of the boys at their apparent first infection.Male and female urinary tract infections (UTI) in childhood show some clinical differences. A greater proportion of male than of female infections appears during the first month of life (Smellie et al., 1964;Stansfeld, 1966;Smallpeice, 1968). Males show a higher ratio of obstructive malformations (DeLuca, Fisher, and Swenson, 1963;Stansfeld, 1966), which, however, does not explain the early onset (Laplane and Etienne, 1968; Bergstrom et al., 1971). Smallpeice (1966) noticed a sex difference in the frequency of haematuria in UTI and made a plea for the inclusion of sex incidence in reports both on clinical and experimental work. However, mixed materials are still used for conclusions regarding aetiology, radiology, and natural history of UTI as if the disease were identical in males and females. The aim of the present investigation is to examine the clinical features of urinary infections with onset between the ages of 1 and 16 years in males and to compare these data with those of a matched female material. Material and MethodsDuring the period [1960][1961][1962][1963][1964][1965][1966] 49 boys aged 1 to 16 years and living in the town of Goteborg appeared in the Children's Hospital with their apparent first UTI. Since the town has only one paediatric department and few private practitioners, the material can be considered as unselected.

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Section: Methodsmentioning

confidence: 99%

Sex Differences in Childhood Urinary Tract Infection

Bergström¹

1972

Archives of Disease in Childhood

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“…Hospital isolates of Providence are well known to be resistant to a wide range of antibiotics (Middleton, 1958;Tomaschoff, 1969;Dobrey, 1971;Graevenitz and Nourbakhsh, 1972), and Li and Miller (1970) have suggested that this property of multiple antibiotic resistance could well favour the increasing significance of this organism as an agent of infection Received for publication 12 February 1976 in the hospital environment. The particular situation that the organism seems to favour, the urinary tract that is undergoing instrumentation, is one where it is likely to be exposed to antiseptics (Gillespie et al, 1967;Desautels, 1969;Stickler et al, 1971).…”

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confidence: 99%

Sensitivity of Providence to antiseptics and disinfectants.

Stickler¹,

Thomas²

1976

J Clin Pathol

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SYNOPSIS Seventy isolates of Providence were obtained from urinary tract infections in patients from five hospitals. They were all identified as Providence B (Providencia stuartii). A typing system was devised for these organisms based on their production of and sensitivity to bacteriophage and bacteriocins. Using this system, 27 distinct strains were recognized, and it was clear that many patients had been infected with the same strain. The minimum inhibitory concentrations of six antiseptics and disinfectants for these strains were determined. Many of the strains were up to 300-fold more resistant to the cationic antiseptics chlorhexidine, cetrimide, and Resiguard than the control strain Escherichia coli NCTC 10418. The sensitivities of the Providence strains to Hycolin, glutaraldehyde, and phenyl mercuric nitrate, however, were similar to those of the control organism. There were significant correlations between the sensitivities of the strains to the three cationic antiseptics. The loss of chlorhexidine resistance from a Providence strain after exposure of the cells to Nmethyl-N' nitro N nitrosoguanidine resulted in a concomitant loss of resistance to cetrimide and Resiguard, but there was no significant increase in the sensitivity of the mutants to the other three antibacterials.

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“…In children without obstructions of the urinary flow, 80% of first UTIs are caused by E. coli (3), and E. coli are isolated from the majority of patients with bacteriuria both among hospital patients and outpatients. In patients with recurrent UTI, obstructions, stones, residual urine, etc., P. mirabilis become increasingly common (14). The deficient attachment to bladder epithelial cells of the P. mirabilis strains tested in the present study may indicate that Proteus colonize the vaginal and periurethral area as efficiently as E. coli, but are eliminated more easily from the bladder at voiding unless there is residual urine, obstructions, or other predisposing factors.…”

Section: -mentioning

confidence: 68%

Attachment of Proteus mirabilis to human urinary sediment epithelial cells in vitro is different from that of Escherichia coli

Edén¹,

Larsson²,

Lomberg³

1980

Infect Immun

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The in vitro attachment of 335 Proteus mirabilis strains from various human sources to human urinary tract epithelial cells was measured. No significant difference in adhesive capacity was found between P. mirabilis strains isolated from the blood of 89 patients with bacteremia, the stools of 36 healthy subjects and 56 patients with diarrhea, and the urine of 62 adults and 92 children with bacteriuria. High mean adhesion values were observed in all groups. The P. mirabilis strains attached only to squamous cells and not to transitional epithelial cells, whereas most of the Escherichia coli strains tested attached to both cell types; strains from patients with acute pyelonephritis attached more often than those from patients with acute cystitis or asymptomatic bacteriuria. The attachment of P. mirabilis to squamous epithelial cells was high about day 15 of the menstrual cycle of the epithelial cell donor, but low at the beginning and the end of the cycle. In contrast, the attachment of E. coli to squamous and transitional epithelial cells did not vary significantly with the menstrual cycle of the cell donor. Differences in adhesion characteristics of E. coli and P. mirabilis may relate to the differences in clinical appearance of urinary tract infections produced by the two organisms.

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Die Ökologie und Bedeutung der Proteusgruppe

Cited by 7 publications

References 43 publications

Sex Differences in Childhood Urinary Tract Infection

Sex Differences in Childhood Urinary Tract Infection

Sensitivity of Providence to antiseptics and disinfectants.

Attachment of Proteus mirabilis to human urinary sediment epithelial cells in vitro is different from that of Escherichia coli

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