Die Olliersche Krankheit

Bethge, Jörn F. J.

doi:10.1055/s-0028-1111790

Cited by 13 publications

(6 citation statements)

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“…In case of segmental opening disorders the bone grew past the persistent CN thereby pushing them towards the diaphysis. Corresponding with the characteristics of the disease and with the majority of reports in humans, the enchondromas were only found in enchondral ossifying bones (1)(2)(3)(4). The enchondromas developed either as a result of internal remodelling disorders out of remains of the epiphyseal growth plates or out of an abnormal metaplasia with formation of cartilage instead of bone in the ossification zone (5).…”

Section: Discussionmentioning

confidence: 56%

Multiple Enchondromatosis in the Dog

Krauser¹

1989

Vet Comp Orthop Traumatol

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SummaryData is presented of the post-mortem macroscopic and microscopic examination of two Toy Poodles with multiple enchondromatosis (Oilier syndrome). In both animals opening and maturation disorders of the growth plates were found in several skeletal locations. Due to the dogs’ age difference at necropsy (14 and 4 months), some variation was also present in occurrence and appearance of primary and secondary alterations, which gave rise to some conclusions regarding development and progression of the disease. Chondrodysplasia, a characteristic of several breeds, is considered to be the essential factor in the pathogenesis of multiple enchondromatosis in the described cases.

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Section: Discussionmentioning

confidence: 56%

Multiple Enchondromatosis in the Dog

Krauser¹

1989

Vet Comp Orthop Traumatol

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“…Zur Ätiologie und Pathogenese der Enchondromatose bestehen noch uneinheitliche Meinungen: Als Ausgangspunkt der Enchondrome werden von einigen Autoren "versprengte Knorpelinseln" angenommen (Hel/ner, 1936;Geschickter u. Copeland, 1936), die aus dem epiphysären Wachstumsknorpel (Bethge, 1962, Langenskjöld, 1947 oder aus dem Perichondrium und gelenkbildenden Knorpel (Aegeter u. Kirkpatrick, 1975) stammen sollen. Die Autoren vermuten, daß diese Knorpelinseln im Verlauf des Wachstums zur Diaphyse wandern und nicht verknöchern.…”

Section: äTiologie Und Pathogeneseunclassified

“…Die Autoren vermuten, daß diese Knorpelinseln im Verlauf des Wachstums zur Diaphyse wandern und nicht verknöchern. Es werden aber auch Störungen der Blutzufuhr in den metaphysären Gefäßen während des enchondralen Knochenwachstums diskutiert (Bethge, 1962). Als Stütze für die auf Experimenten von Trueta (1957) fußende Auffassung gilt die längliche, im Versorgungsgebiet metaphysärer Gefäße entsprechende Form mancher Knorpelherde und die Begrenzung der Tumorentstehung auf die Zeit des enchondralen Wachstums.…”

Section: äTiologie Und Pathogeneseunclassified

“…Es wird betont, daß wachsende, die Funktion oder das Aussehen der Hand störende Tumoren bereits im Kindesalter operiert werden sollen, aber längst nicht jedes Enchondrom im Rahmen einer Enchondromatose dieser Behandlung bedarf. von vielen Autoren bezweifelt (W. Mül/er, 1937;Gaede, 1938;Chrysopathes, 1929;Bethge, 1962;Hel/ner, 1950;Frangenheim, 1913;Herzog, 1944;Exner, 1950;Cording u. Rütt, 1982;Spranger, Langer u. Wiedemann, 1974). Bei genauer Untersuchung der nicht befallenen Seite können nämlich auch dort knöcherne Veränderungen zu finden sein.…”

Section: Formen Und Lokalisationenunclassified

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Enchondromatosen der Hand

Blauth¹,

Sönnichsen²

2008

Z Orthop Ihre Grenzgeb

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In the introduction the authors report on the suspected theories of origin of the enchondromas: some believe that they are the result of disintegration of islands of cartilage from the epiphyseal growth cartilage, while in the opinion of others they are brought about by disturbances of blood supply in the metaphyseal vessels during enchondral growth. No evidence of heredity has yet been established. Surgical treatment and late results are described taking the course of disease of a patient who is now 33 years old as an example. This patient had grotesque tumors on both hands; the tumors not only disfigured the limbs but also constituted a functional handicap. Surgery was indicated for both esthetic and functional reasons. For large tumors, with destruction of the substantia corticalis or regions close to the joint, cross-section or segmental resection is given as the therapy of choice, and if possible segmental resection is to be preferred, filling the defect with loosely emplaced autologous spongiosa. After this procedure the hand does not have to be immobilized for as long as after a cross-section. In this patient, after a total of 16 procedures on both hands, there have been no recurrences in the ten years of the follow-up period. The same applies to two other patients with multiple enchondromas (which were admittedly less severe) who were followed up between 3 and just under 8 years after surgery. It is stressed that growing tumors which disturb the function or appearance of the hand should be surgically treated in childhood, but that by no means every enchondroma seen in enchondromatosis requires such therapy.

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“…In man the unilaterally occurring enchondromatosis was formerly known as Ollier's disease. However, this term is now also used for the generalised form as, particularly in later stages of the condition and on careful examination, enchondromata can also be demonstrated in bones on the apparently unaffected side of the body (1,2,3). In comparison, little is known about multiple enchondromatosis in animals.…”

Section: Introductionmentioning

confidence: 99%

Multiple Enchondromatosis in the Dog

Matis¹,

Krauser²,

Schwartz-Porsche³

et al. 1989

Vet Comp Orthop Traumatol

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SummaryThe clinical and radiological findings of three related Miniature Poodles with multiple enchondromatosis (Ollier’s disease) are presented. Persisting, in part ossified growth plate cartilage foci were found bilaterally in the humerus, radius, ulna, femur, tibia and fibula of each dog and in one dog in some metacarpal and metatarsal bones. The ribs and many vertebral bodies were also affected. There was evidently no bone formation in the sternebrae. All three dogs first attracted attention at the ages of four to six months, with spontaneous bilateral femoral neck fractures. The mode of inheritance of the condition is not yet clear, but based on the known pedigree data a dominant effect appears unlikely.

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Die Olliersche Krankheit

Cited by 13 publications

References 0 publications

Multiple Enchondromatosis in the Dog

Multiple Enchondromatosis in the Dog

Enchondromatosen der Hand

Multiple Enchondromatosis in the Dog

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