Die Pathogenese der zentralserösen Chorioretinopathie

Abstract

Of the patients 47 (96%) showed hypofluorescent areas in the early pictures of the ICG angiography which changed to hyperfluorescence in the late phase pictures in 39 patients (80%). Of the asymptomatic paired eyes, 31 (63%) showed abnormalities in the ICG pictures. The amplitudes in mERG were reduced in the study eyes as well as in the paired eyes and only recovered slowly. Angiographic healing was seen in 44 (90%) patients during the follow-up time, while the reduction of mERG amplitudes recovered more slowly and did not reach normal levels. CSC is a bilateral disease of the central choroid with acute decompensation of the retinal pigment epithelium in one eye. This leads angiographically to a local hypofluorescence with subsequent hyperfluorescence caused by barrier breakdown. The functional recovery follows the morphological healing only slowly. The mERG seems to be an adequate measurement method.

The Association between Choroidal Thickness Variations and Response to Intravitreal Bevacizumab in Central Serous Chorioretinopathy

“…Classically, barrier function defect in the retinal pigment epithelium is considered to be the main pathogenesis mechanism in CSC eyes. However, advances in ICGA indicate that abnormal choroidal vasculature might be the primary pathogenic cause of CSC [ 1 , 6 ]. If the abnormal choroidal vasculature is the main pathogenic mechanism of CSC eyes, the role of VEGF might be emphasized and provide legitimacy of the anti-VEGF therapy to CSC eyes.…”

“…that is usually associated with a good visual prognosis. In some cases, however, persistent CSC results in permanent damage to the retina or retinal pigment epithelium [ 1 , 2 , 3 , 4 , 5 ]. Therefore, if the disease continues beyond the acute phase, active treatment must be considered to prevent irreversible damage to retinal function.…”

Ketoconazole in the treatment of central serous chorioretinopathy: a pilot study

“…Various risk factors for CSCR have been identified, including male gender, stress, type A personality, pregnancy, arterial hypertension, elevated catecholamines, genetic disposition, psychopharmacological medication, diabetes mellitus, previous eye surgery, and use of antibiotics, alcohol and antihistamines (Gelber & Schatz 1987; Yannuzzi 1987; Tittl et al. 1999; Dohrmann et al. 2001; Wynn 2001; Bouzas et al.…”