Although the fact that migrants show a lower psychological health status than non-migrants is clearly demonstrated by a lot of studies, the connection between migration conditions and psychological health status is seldom analyzed. To close this lack of research 140 Polish and 82 Vietnamese migrants in Leipzig were examined by the anxiety- and depression scale of the HADS and more over asked questions about their cognitive, social, occupational, identificative assimilation status and their perceived discrimination. Both migrant groups showed a higher level of depressive and anxious symptoms than Germans. In regression analyzes only social assimilation and perceived discrimination had a significant influence, language skills and structural (occupational) assimilation could not explain depression or anxiety, but there were differences in regression models between both groups. Beside problems in operationalization, different migrant biographies and structural conditions have to be discussed as reason for these results.