Die Regenerationsfähigkeit des Beckenkammes nach Spongiosaentnahme beim Menschen—Induktion durch Phosphatkeramiken? Teil I

Roesgen, M.

doi:10.1007/bf02589879

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Cited by 4 publications

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“…As a rule, replenishing bony defects can be accomplished by spongious transplantation of cancellous bone or with the assistance of bone replacement material. Thereby, the four primary differentiated transplantation groups are [1][2][3][4]:…”

Section: Introductionmentioning

confidence: 99%

Bone Replacement Materials in Hand Surgery

Friesen

Schäfer

2006

Eur J Trauma

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Section: Introductionmentioning

confidence: 99%

Bone Replacement Materials in Hand Surgery

Friesen

Schäfer

2006

Eur J Trauma

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Missing osteoconductive effect of a resorbable PEO/PBT copolymer in human bone defects: A clinically relevant pilot study with contrary results to previous animal studies

Roessler

Wilke

Griss

et al. 2000

J. Biomed. Mater. Res.

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PEO/PBT 70/30 (POLYACTIVE(R) 70/30), a degradable porous copolymer with elastic properties, was found to be osteoconductive in many animal studies. The aim of this study was to determine the osteoconductive effect in a human paired control iliac defect model. In seven patients undergoing anterior spinal interbody fusion surgery, two bicortical iliac defects for autograft harvesting were created. The defect size was identical for both defects measuring about 40 x 15 mm (group I). One defect was filled with the degradable implants, whereas the remaining one was left untreated as a control. The defect site for treatment was chosen randomly. In three further patients, only one defect measuring about 40 x 35 mm was created (group II). All patients were examined clinically and radiologically by spiral-CT after 1, 6, 12, 24, and 52 weeks. Three-dimensional reconstructions as well as CT-volumetric measurements using 1 mm sections were used as evaluation methods. In group I, a two-tailed paired t-test showed that the treated defects had significantly less formation of new bone than the untreated ones (p < 0.05 after 12 weeks, p < 0.01 after 52 weeks). Also, in group II, not much bone ingrowth could be observed. The histological evaluation of one patient in group I revealed no bone within the pores, and a fibrous layer between bone and implant was always present. Therefore, PEO/PBT 70/30 cannot be recommended as a bone substitute for clinical use. Differences in bone regeneration between humans and certain animal species as well as inapplicable defect models in previous animal studies are discussed as possible reasons for the failure.

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