Die Revitalisierung des bovinen Xenograft als Gefäßersatz beim Hund

Abstract

In 16 mongrel dogs bovine xenografts of 4 to 12 cm of length were used for arterial replacement. The grafts were removed after 30 minutes and up to 13 months for electronmicroscopic examination. The graft was shown to be significantly thrombogenic during the first six weeks after implantation. After 8 to 10 weeks an increasing revitalization of the graft is found starting from the ends of the canine artery. A cover of endothelial cells is formed in the graft lumen. The graft wall is enforced by formation of collagen and elastic fibers originating from capillaries and fibroblasts. Revitalization of the graft is limited to a rim of 2 to 3,5 cm next to the anastomoses with the canine artery. The remaining graft segment shows revitalization only on the outside wall. Degenerative changes take place in the inner layer of the graft with time passing.

Alloplastic Replacement of Canine Trachea with Dacron*

“…Such disturbances of differentiation are also known to occu r in inflammato ry responses (l , 29) , but we we re unable t o demonstrate inflamma tio n in our experiments, and so could exclude this aspect as causa tive. Scholzel and co-workers (26) as weil as Strauss (29), on acco unt of their experiments, pointed out that the poor vascular supply o f the subepit helial co nnective tissue layer may be respon sible for disturbances in cell differe ntiat ion . Since a relatively den se connective tissue was found in our ex periments, we would Iike to suggest that inadequ ate vascularizat ion in th e center of the imp lant may have been responsible for the dist urbance s of differentiation of the epithelium.…”