Die Risiken der vorderen Kreuzbandplastik bei offenen Wachstumsfugen. Eine experimentelle Untersuchung

Seil, R.; Pape, D; Kohn, Donald B.

doi:10.1055/s-2003-821926

Cited by 2 publications

(8 citation statements)

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“…They found a hyperplasia of the growth plate and a loss of the classical cellular architecture of this specific cartilage. This could be confirmed by other studies (Seil 2002). Filling a bony tunnel completely by a tendon graft could not prevent the formation of a bone bridge on a systematic basis.…”

Section: Introductionsupporting

confidence: 90%

“…Filling a bony tunnel completely by a tendon graft could not prevent the formation of a bone bridge on a systematic basis. On the contrary, an incomplete filling of the tunnel by a tendon graft of a lesser diameter did not systematically result in the formation of a bone bridge (Seil 2002).…”

Section: Introductionmentioning

confidence: 99%

“…In a previous animal study on 4 months old sheep, we obtained a severe malalignment of the distal femoral physis by drilling a 5 mm tunnel through the perichondral structures and by avoiding to fill the tunnel with a tendon graft. An MRI analysis of the injured bones at 10 months revealed that the injured size of the perichondral structures was 3‐5% of the size of the entire perichondral circumference (Seil 2002). Further studies need to confirm these data and to evaluate more precisely at which time point of the growth period and from which amount a localized peripheral growth plate injury may become deleterious for further longitudinal growth.…”

Section: Introductionmentioning

confidence: 99%

“…implantation of biodegradable materials and the authors did not recommend the use of such transphyseally placed implants in pediatric ACL reconstruction (Seil 2002).…”

mentioning

confidence: 99%

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Surgical-experimental principles of anterior cruciate ligament (ACL) reconstruction with open growth plates

2015

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ObjectiveTo review surgical and animal experimental studies performed with open growth plates in relation with pediatric anterior cruciate ligament (ACL) reconstruction.BackroundWhen it comes to the treatment of ACL injured children, there is a lack of current international guidelines, leaving the treating physicians with a therapeutic dilemma. A variety of surgical and animal experimental studies have been undertaken over the last decades in relation with open growth plates and ACL-reconstruction.MethodBased on our own previous animal experimental data, we highlighted 15 specific points concerning pediatric ACL-reconstruction and reviewed additional literature concerning these individual items.ResultsPediatric ACL-reconstruction could be proven to be safe in animal models. Growth abnormalities, risk factors and factors, which were specifically related to biological healing processes in children, were identified. From them surgical principles for safe pediatric ACL replacements can be deducted. Applying these principles through a correct technical execution of surgery may prevent clinically significant growth changes.ConclusionOver the last 2 decades it has been shown that a technically correct pediatric ACL reconstruction has little risk in creating clinically significant growth abnormalities. Animal experiments support this hypothesis despite the fact that the gained knowledge cannot be fully generalized to humans. More long time follow-up is needed to fully understand the complete risk factors related to ACL surgery with open growth plates.Electronic supplementary materialThe online version of this article (doi:10.1186/s40634-015-0027-z) contains supplementary material, which is available to authorized users.

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Section: Introductionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…implantation of biodegradable materials and the authors did not recommend the use of such transphyseally placed implants in pediatric ACL reconstruction (Seil 2002).…”

mentioning

confidence: 99%

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Surgical-experimental principles of anterior cruciate ligament (ACL) reconstruction with open growth plates

2015

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“…Studies on the longitudinal growth of the sheep forearm revealed that they reached 70% of their adult height at day 20 and 90% at day 167 (Salomon 2001). Supposing that these data could be transferred to the hind limb of this species, the use of 4‐months old sheep appears justified, and grossly 4 cm of longitudinal hind limb growth could be expected at this age (Seil 2003). This sheep model was used to evaluate the risk for growth disturbances of transphyseal drilling and ACL reconstruction (Seil et al 2008).…”

Section: Reviewmentioning

confidence: 99%

Large animal models in experimental knee sports surgery: focus on clinical translation

et al. 2015

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Large animal models play a crucial role in sports surgery of the knee, as they are critical for the exploration of new experimental strategies and the clinical translation of novel techniques. The purpose of this contribution is to provide critical aspects of relevant animal models in this field, with a focus on paediatric anterior cruciate ligament (ACL) reconstruction, high tibial osteotomy, and articular cartilage repair. Although there is no single large animal model strictly replicating the human knee joint, the sheep stifle joint shares strong similarities. Studies in large animal models of paediatric ACL reconstruction identified specific risk factors associated with the different surgical techniques. The sheep model of high tibial osteotomy is a powerful new tool to advance the understanding of the effect of axial alignment on the lower extremity on specific issues of the knee joint. Large animal models of both focal chondral and osteochondral defects and of osteoarthritis have brought new findings about the mechanisms of cartilage repair and treatment options. The clinical application of a magnetic device for targeted cell delivery serves as a suitable example of how data from such animal models are directly translated into in clinical cartilage repair. As novel insights from studies in these translational models will advance the basic science, close cooperation in this important field of clinical translation will improve current reconstructive surgical options and open novel avenues for regenerative therapies of musculoskeletal disorders.

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Die Risiken der vorderen Kreuzbandplastik bei offenen Wachstumsfugen. Eine experimentelle Untersuchung

Cited by 2 publications

References 0 publications

Surgical-experimental principles of anterior cruciate ligament (ACL) reconstruction with open growth plates

Surgical-experimental principles of anterior cruciate ligament (ACL) reconstruction with open growth plates

Large animal models in experimental knee sports surgery: focus on clinical translation

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