Die Rolle der interstitiellen Brachytherapie bei der Behandlung von Tumoren der Vagina und Vulva

Abstract

IBT achieved good local control without serious delayed side effects in both localizations. However, survival is limited by regional or distant metastases.

Radical interstitial HDR brachytherapy in treatment of recurrent vulvar cancer: a case study

“…Other authors also observed a low number of complications [9,14,18]. Jolicoeur observed acute toxicity grade 2 in all patients but late severe toxicity only in two women [18].…”

“…There are only few reports in the literature concerning recurrent vulvar cancer treated with interstitial HDR brachytherapy [9,18,19]. It may be used as a "boost" or as a sole treatment.…”

“…It is well documented that interstitial brachytherapy makes it possible to achieve a very good local control [9,13,15,16,18,19]. Jolicoeur described patients with early vulvar cancer (Tis, T1N0M0) and recurrent carcinoma (in situ) who were treated with interstitial HDR brachytherapy.…”

“…Interstitial HDR brachytherapy delivers a high dose of radiation strictly to the tumour while sparing the adjacent healthy tissues. Due to the sensitive nature of the vulvar tissues, interstitial brachytherapy offers an effective, gentle and individualized therapy in a short time [9].…”

“…Local failures are the most frequent while and groin recurrences are less common [6]. It is estimated that even in multimodality treatment, about 10-20% of patients with FIGO I and 50-70% with the advanced disease will recur [5,[7][8][9] and 40% of them will die [5].…”