Die seltene Kombination: persistierender Ductus arteriosus und Pulmonalstenosen. Besteht ein Zusammenhang mit der Rötelnembryopathie?

Abstract

The combination of patent ductus arteriosus, valvular pulmonary stenosis and/or peripheral pulmonary stenosis is very rare. We examined 23 children with this entity. In 9 children there were findings suggestive of rubella syndrome. 17 of the 23 children were born predominantly between October and March. Most of them showed low birth weights. Regarding the cardiac involvement there was no difference between the children with signs of rubella syndrome and those without noncardiac manifestations. In many children the symptoms of the patent ductus are leading. On evaluation of the noninvasive diagnostic procedures the ECG showed often a right ventricular hypertrophy and the x-ray of the chest showed in most cases a cardiac enlargement. In all patients a heart catheterization was necessary to establish the diagnosis. The review of the literature and the interpretation of our findings seems to suggest that the combination of a patent ductus arteriosus with pulmonary stenosis is a typical manifestation of rubella infection in the heart.

Massive Dilatation of the Pulmonary Artery in Association with Pulmonic Stenosis and Pulmonary Hypertension

“…First, an isolated bicuspid pulmonic valve in the absence of other congenital defects is exceedingly rare. [2] While it is associated with maternal rubella infection,[3] our patient had no knowledge of any complication during his mother's pregnancy. As in patients with bicuspid aortic valves, a bicuspid pulmonic valve tends to calcify over time, leading to significant stenosis.…”