Die sogenannte ?pregnancy zone?, ein neuer Serumfaktor bei Schwangeren

Trophoblast-Specific Beta₁-Glycoprotein as a Marker for Pregnancy and Malignancies

“…Subsequently, two different pregnancyassociated components were found in a-and j3-globulins of pregnant sera by immunoelectrophoresis in agar (30). Further immunological investigations also demonstrated the presence of several pregnancy-associated antigenic components both in a-and /3-globulins of pregnant sera and placental extracts (4,5,9,26,31,32,39,43,44,62,66,68,76,77,99). Using monospecific antisera to several pregnancy-associated plasma proteins, Lin et al (44) carried out comparative immunodiffusion analysis of different pregnancy-associated antigens which were reported from various laboratories.…”

Immunological Comparison of Various Human Pregnancy-Associated Plasma Proteins

“…The immunological 'reactions of identity' seen above with pregnancy plasma and specific antisera to the PZP [2,3,5,[15][16][17], «,-pregnoglobulin [9], SP3 [10], Xh [13,14,30], PAG [7], Pal [8], new serum «»-macroglobulin [11], and pregnancy-associated a2-globulin [12] were unequivocal, and were never associated with spur formation. These findings confirm and extend more limited observations of other investigators, e. g., the finding of identity between SP3, Xh and PZP by B o h n [10]; the identification of «2-pregnoglobulin with Xh, PAG, and Pal by B e r n e [31], of Xh with Pal [13], of Xh with pregnan cy zone by H o f m a n n et al [32], and of PAG with Pal by H o r n e et al [7].…”

“…These include the proteins designated: pregnan cy-associated globulin (PAG) [7]; Pal [8]; a2-pregnoglobulin [9]; SP" SP._" and SP3 [10]; new serum a-macroglobulin [11]; pregnancy-asso ciated «o-globulin [12]; Xh protein [13,14]; as well as pregnancy zone [15][16][17]. Some of these, e. g., Xh and Pal, were originally described as sex-linked normal protein allotypes seen in a varying proportion of fem ales but less frequently in males [8,14].…”

Electrophoresis

“…Recent investigations of normal serum proteins in adults ( 1297) are usually concerned with distributions on media other than paper, such as cellulose acetate (2038), polyacrylamide gel (1731), urea-starch gel (1982), and anion-exchangers (779), or with special populations-e.g., racial groups (1721,2027,2251) and the aged (2423). Much interest has centered around special proteins such as the group specific proteins (149,287,914,940,1135,1565,1842), immune globulins (389, 504, 599, 867, 899, 918,1880,1906,1908,1989,2124,2221,2255), and previously unreported fractions such as normal double albumin fractions (1873,2201), pink pigmented plasma proteins (1994), and a zone that appears in pregnancy (20,485,2409), or fractions that inhibit bacterial growth (2001). There are studies of normal distributions of serum proteins (281), including immunoglobulins (635), in neonates and infants and in children (1435,1613,2283).…”