“…Paper electrophoretic studies of the cerebrospinal fluid in infectious diseases of the central nervous system (1,2,3) have revealed some qualitative changes of the proteins, the changes varying with the course of the disease. Any change in a single protein fraction must, however, be considerable before it can produce a significant abnormality of the pertinent protein group in paper electrophoresis or be demonstrated by salting out methods or by colloidal reactions.…”