Die Wirkung quantitativ abgestufter Drosselung der Nierendurchblutung auf den Blutdruck

Enger, R.; Linder, F; Sarre, H

doi:10.1007/bf02598336

Cited by 33 publications

(4 citation statements)

References 4 publications

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“…All these circumstances argue against the physiological significance of the results. It may also be noted that Enger and Gerstner (24) report that a vasopressor principle appears in the blood in consequence of momentary renal ischemia; Enger, Linder, and Sarre (25) report that the blood pressure begins to rise within 1 hour after partial clamping of the renal artery, while Verney and Vogt (105) report a rise in 20 to 30 minutes. Whether this rapidly developing constriction involves the renal circulation itself has not been determined, but it is possible that it does.…”

Section: The Evidence Bearing On the Autononmy Of The Peripheral Artementioning

confidence: 99%

The Effects of Spinal Anesthesia on the Circulation in Normal, Unoperated Man With Reference to the Autonomy of the Arterioles, and Especially Those of the Renal Circulation

Smith

Rovenstine²,

Goldring³

et al. 1939

J. Clin. Invest.

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The present study, comprising observations on 21 subjects given high spinal anesthesia, is an investigation of the effects of anesthetic denervation in normal man, uncomplicated by surgical intervention, on the circulation with particular reference to the vascular bed of the kidney. It is concluded that the renal arterioles are distinctly autonomous, in the sense that under basal conditions the renal vascular tone is not affected by anesthetic denervation. Our observations further suggest that the arteriolar bed generally (apart from the skin) possesses considerably more autonomy than is usually attributed to it-sufficient, in fact, in the normal supine individual at rest, to maintain an essentially normal arterial pressure. We find no evidence of significant arteriolar dilatation during high spinal anesthesia, such reduction in blood pressure as occurs being attributable, we believe, to diminished circulating blood volume in consequence of dilatation of the capillaries, venules, and veins.Part I deals with the following topics: (1) Methods; (2) the effects of spinal anesthesia on renal blood flow; (3) on the arterial pressure, and (4) on the reflex responses to posture, hypercapnia, and anoxemia. Part II consists of a review of the evidence on (5) the existence of tonic vasoconstrictor activity and on (6) the existence of autonomy in the peripheral arterioles generally, and (7) in the kidney in particular, and (8) the peripheral effects of hypercapnia and anoxemia. In (5) it is brought out that the notion of tonic vasoconstrictor activity in the sympathetic nervQus system, apart from the skin, is based largely upon animal experiments which are seriously complicated by general anesthesia, venous dilatation, etc., and that the information so obtained cannot be transferred with confidence to normal animals, and certainly not to man.PART I MethodsThe subjects were male convalescent patients ranging in age from 18 to 50 years who, with a single exception, presented no abnormal signs contraindicating selection for this study. They were examined in the morning in the basal, fasting condition, and were prepared for the measurement of renal blood flow and filtration rate by the clearance method, as described by Smith, Goldring, and Chasis (93). In the earlier observations the phenol red and inulin (35) clearances were followed, but after the introduction of the diodrast clearance (93), all three clearances were used. The phenol red clearance serves as a check on the diodrast clearance, the constancy of the phenol red/diodrast clearance ratio before and after anesthesia demonstrating that procaine per se has no effect upon the tubular excretory mechanism. The infusions corresponded to the typical infusion cited by Chasis, Ranges, Goldring, and Smith (18). Zero time was taken as the beginning of the priming infusion, which occupied about 10 minutes; the infusion was then changed to the sustaining infusion, the first urine collection period being started at about 30 minutes. The sustaining infusion was usually interrupted ...

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Section: The Evidence Bearing On the Autononmy Of The Peripheral Artementioning

confidence: 99%

The Effects of Spinal Anesthesia on the Circulation in Normal, Unoperated Man With Reference to the Autonomy of the Arterioles, and Especially Those of the Renal Circulation

Smith

Rovenstine²,

Goldring³

et al. 1939

J. Clin. Invest.

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“…Pressor or vasoconstrictor properties of the renal venous blood appear not only in chronic ischaemia of the kidney, but can also be detected a few minutes after the compression of the artery of a normal kidney [Enger, Linder & Sarre, 1938;Verney & Vogt, 1938a;Grimson, 1939; Braun-Menendez . We have repeated and confirmed some of the experiments on the pressor and vasoconstrictor properties of the blood from ischaemic kidneys and studied some of the properties of the active substance of this blood.…”

mentioning

confidence: 99%

The substance causing renal hypertension

Braun-Menendez¹,

Fasciolo²,

Leloir³

et al. 1940

The Journal of Physiology

348

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“…Blood flow through the kidneys has been studied by a number of methods and considerable information is available on this subject, t Since Goldblatt (3) produced experimental arterial hypertension by reducing renal blood flow by means of an adjustable clamp placed on the renal arteries, interest has been aroused in the relation of the renal circulation to arterial pressure. Blood flow through kidneys the arteries of which have been partially constricted, has been measured both before and after hypertension had developed (4,5). The present study was the outgrowth of an attempt to observe the behavior of the renal circulation while experimental renal ischemia was being induced by partial arterial constriction, and to test whether elevation of blood pressure can be produced in brief experiments by this method, as has been reported (4,6).…”

mentioning

confidence: 99%

“…Blood flow through kidneys the arteries of which have been partially constricted, has been measured both before and after hypertension had developed (4,5). The present study was the outgrowth of an attempt to observe the behavior of the renal circulation while experimental renal ischemia was being induced by partial arterial constriction, and to test whether elevation of blood pressure can be produced in brief experiments by this method, as has been reported (4,6).…”

mentioning

confidence: 99%

The Behavior of Renal Blood Flow After Partial Constriction of the Renal Artery

Schroeder

Steele

1940

Journal of Experimental Medicine

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1. Studies have been made of the behavior of renal blood flow after partial constriction of the renal artery in twenty-four dogs. 2. When reduction in renal blood flow is produced by partial constriction of the renal artery, a readjustment of flow in the direction of normal occurs within a few minutes, subsequent constriction being again followed by a return of flow toward normal until the artery is markedly constricted. 3. Renal blood flow after marked constriction of the artery becomes extremely susceptible to the vasoconstrictive action of small doses of adrenalin, and flow may cease with larger doses for a considerable period of time. 4. Arterial hypertension of significant degree may follow partial constriction of one renal artery during brief experiments when adrenalin in addition has been administered. 5. Further evidence is presented in favor of the concept that the renal circulation enjoys a control independent of systemic arterial pressure.

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Die Wirkung quantitativ abgestufter Drosselung der Nierendurchblutung auf den Blutdruck

Cited by 33 publications

References 4 publications

The Effects of Spinal Anesthesia on the Circulation in Normal, Unoperated Man With Reference to the Autonomy of the Arterioles, and Especially Those of the Renal Circulation

The Effects of Spinal Anesthesia on the Circulation in Normal, Unoperated Man With Reference to the Autonomy of the Arterioles, and Especially Those of the Renal Circulation

The substance causing renal hypertension

The Behavior of Renal Blood Flow After Partial Constriction of the Renal Artery

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