“…However, it has been doubted that there is a sustained direct effect on muscle vessels (Duff & Swan, 1951;Whelan, 1952Whelan, , 1954 summarized in Barcroft & Swan, 1953). On the other hand, Bock, Hensel & Ruef (1955) occasionally found a sustained increase in blood flow in the calf muscles (measured with a heated thermocouple probe) with intraarterial infusion. Recent studies by the same method have shown that the direct effect of adrenaline on the vascular bed of the muscle is not limited to the initial dilatation, either with a single dose or with infusion (Golenhofen, 1959).…”