Die Wirkung Von Antipyretischen Und Analgetischen Substanzen Auf Das Menschliche Bronchialasthma Und Das Experimentelle Meerschweinchenasthma

Stresemann, Erwin

doi:10.1111/j.1398-9995.1963.tb03177.x

Cited by 14 publications

(6 citation statements)

References 13 publications

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“…Non-steroidal anti-inflammatory drugs also block the contraction of human isolated bronchial muscle induced by prostaglandin F2a (Collier & Sweatman, 1968) and the production of prostaglandins in human tissues in vitro (Smith & Willis, 1971) and in vivo (Collier & Flower, 1971). Although bradykinin and SRS-A are bronchoconstrictors in man (Herxheimer & Stresemann, 1961aStresemann, 1963b) their antagonism by antipyretic drugs has been unsuccessful in most patients (Herxheimer & Stresemann, 1961b;Stresemann, 1963a). Similarly, the efficacy of these drugs against bronchial asthma, though real in some cases, is generally disappointing (Cook, 1947;Herxheimer & Stresemann, 1961b;Pearson, 1963;Clarke, 1969).…”

Section: Discussionmentioning

confidence: 99%

“…First, the antihistamines and the antiphlogistic acids are more effective against anaphylactic bronchoconstriction in the guinea-pig than against asthma in man. (Herxheimer, 1953;Stresemann, 1963a). Second, steroids beneficial in human asthma, have not been conclusively demonstrated to reduce *Present address: Pharmacology Laboratory, Research anaphylactic bronchoconstriction in the guinea-pig (Harris & Harris, 1950;Humphrey, 1951;Gross & Haefeli, 1952;Herxheimer & Rosa, 1952;Feinberg, Malkiel & McIntyre, 1953;Goadby & Smith, 1964;Fregnan & Suchowsky, 1968;Hicks, 1969).…”

Section: Introductionmentioning

confidence: 99%

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The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat

Collier²,

James

1972

British J Pharmacology

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Summary1. A method for the measurement of anaphylactic bronchoconstriction in the rat is described. 2. Dexamethasone inhibited this response in a dose-related manner. 3. Disodium cromoglycate antagonized the response. A bell-shaped doseresponse curve was obtained with peak activity at 1 mg/kg i.v. 4. Meclofenamate was not active when given alone or in combination with dexamethasone. 5. Methysergide significantly inhibited the response. Mepyramine, atropine, propranolol and adrenalectomy did not significantly modify the response. 6. The relationships of anaphylactic bronchoconstriction in the rat to anaphylactic bronchoconstriction in the guinea-pig and to human asthma are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat

Collier²,

James

1972

British J Pharmacology

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“…Several anti-inflammatory drugs, e.g., aspirin, flufenamate and phenylbutazon, have been shown to antagonize this effect in the guinea pig. Similarly, Stresemann reported a significant increase of the vital capacity or FEV, and peak expiratory flow in 37 asthmatic patients after ingestion of aspirin, dimethylaminophenazon and flufenamate, which may suggest bradykinin as a cause of bronchial narrowing even in human asthma Stresemann, 1963]. Bradykinin has also been mentioned as a possible mediator in connection with exercise-induced asthma [McN eill et al, 1966;Seaton et al, 1969].…”

Section: Introductionmentioning

confidence: 99%

<i>In vivo</i> and <i>in vitro</i> Effect of Bradykinin on Bronchial Motor Tone in Normal Subjects and Patients with Airways Obstruction

Simonsson¹,

Skoogh²,

Bergh³

et al. 1973

Respiration

105

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The bronchoconstrictory effect of bradykinin was studied in vivo on subjects with normal airways and on patients with airways ob struction and in vitro on isolated muscle preparations. Body plethysmographic measurements ofe airways conductance showed that bradykinin in both groups caused bronchoconstriction which probably was due to non-specific irritation of vagal irritant receptors, as it could be blocked by atropine in all but 3 obstructive patients. In these, we assume a more specific direct muscle-constricting effect from bradykinin. The in vitro tests revealed a widerange of sensitivity to bradykinin; muscles from patients with airways obstructionshowed an increased sensitivity to bradykinin.

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“…Antagonism of the bronchoconstrictor action of SRS-A in the guinea-pig by acetylsalicylic acid and other nonsteroid anti-inflammatory drugs was also reported in our preliminary communication (Berry et al, 1963). Since several of these drugs have antiasthmatic action in man (Herxheimer & Stresemann, 1961;Stresemann, 1963), we have explored their antagonism of SRS-A-induced bronchoconstriction more thoroughly.…”

mentioning

confidence: 99%

Bronchoconstrictor Action and Antagonism of a Slow‐reacting Substance From Anaphylaxis of Guinea‐pig Isolated Lung

Berry¹,

Collier²

1964

British Journal of Pharmacology and Chemotherapy

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Slow‐reacting substance produced in anaphylaxis (SRS‐A) increased resistance of the lungs to inflation in the guinea‐pig in vivo and caused isolated preparations of its tracheobronchial muscle to contract. SRS‐A also contracted human isolated bronchial muscle and some but not all preparations of rabbit trachea. Nonsteroid anti‐inflammatory drugs, which antagonize bronchoconstriction induced by kinins, but not that by histamine, acetylcholine, 5‐hydroxytryptamine, substance P, angiotensin or lung prostaglandin, also antagonized the bronchoconstrictor action of SRS‐A. This antagonism resembled that of kinins in being surmounted by higher doses of agonist, in the potencies of active drugs and in the types of drugs which were inactive. However, receptors in guinea‐pig tracheobronchial muscle for SRS‐A seem to be distinct from those for bradykinin, since preparations of this muscle could become unresponsive to either agent in vivo and in vitro, while remaining responsive to the other.

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Die Wirkung Von Antipyretischen Und Analgetischen Substanzen Auf Das Menschliche Bronchialasthma Und Das Experimentelle Meerschweinchenasthma

Cited by 14 publications

References 13 publications

The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat

The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat

<i>In vivo</i> and <i>in vitro</i> Effect of Bradykinin on Bronchial Motor Tone in Normal Subjects and Patients with Airways Obstruction

Bronchoconstrictor Action and Antagonism of a Slow‐reacting Substance From Anaphylaxis of Guinea‐pig Isolated Lung

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