Die Wirkung von Ethrane auf die Hämodynamik und die Sauerstoffversorgung des Myocards im Vergleich zu Halothane

Tarnow, J.; Gethmann, J. W.; Patschke, D.; Reinecke, Alexander; Weymar, A.; Eberlein, H. J.

doi:10.1007/978-3-642-66220-1_23

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…The myocardial depressant effect of enflurane has been well documented in the isolated papillary muscle preparation (1,2), in the intact dog (3,4), in healthy man (5,6) and in patients with coronary artery disease (7). In patients with cardiac disease, enflurane seems to depress the myocardium less than halothane (7).…”

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confidence: 99%

Effects of Enflurane on Coronary Haemodynamics in Patients with Ischaemic Heart Disease

Rydvall

Häggmark

Nyhman

et al. 1984

Acta Anaesthesiol Scand

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The effects of enflurane with and without nitrous oxide on coronary haemodynamics and myocardial oxygenation were investigated in 11 patients with generalised atherosclerotic disease. Enflurane decreased systemic blood pressure (-50%) mainly by systemic vasodilation (SVR -41%) and to a lesser degree by impairment of cardiac performance (CO -27%). A change from 1MAC enflurane-nitrogen-oxygen (70/30) to 1MAC enflurane-nitrous oxide-oxygen (70/30) decreased blood pressure and cardiac output further (-16% and -14%). Enflurane-nitrogen-oxygen decreased coronary blood flow (-29%) and perfusion pressure (-47%). Coronary vascular resistance fell (-20%) along with decreases in myocardial oxygen consumption and extraction (-40% and -16%). Regional coronary blood flow measurements in four of the patients revealed maldistribution of blood flow. During enflurane-nitrous oxide-oxygen, myocardial oxygen consumption and extraction decreased further (-29% and -12%) without change in coronary blood flow or resistance. Myocardial ischaemia was observed in four patients during enflurane-nitrogen. During enflurane-nitrous oxide, ischaemia disappeared in two of the previously ischaemic patients and appeared in two not previously ischaemic. The regional blood flow maldistribution was abolished with nitrous oxide. It is concluded that enflurane is a powerful coronary vasodilator and in this respect slightly less potent than isoflurane. Enflurane may induce myocardial ischaemia by redistributing coronary blood flow and/or by producing hypotension. Nitrous oxide added to enflurane depresses cardiac function and augments the coronary vasodilatory effect of enflurane to a level at which coronary blood flow becomes totally pressure dependent.

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mentioning

confidence: 99%

Effects of Enflurane on Coronary Haemodynamics in Patients with Ischaemic Heart Disease

Rydvall

Häggmark

Nyhman

et al. 1984

Acta Anaesthesiol Scand

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“…Ò' ί ή K' X' X' X (LASSEN, 1959;HORATZ, 1967;AHNEFELD et al, 1970;HIOTAKIS u. LIST, 1971;STAUCH, 1974;TARNOW et al, 1974;SCHMIDT, 1977;HALDEMANN, 1978;SALEHI, 1978;PICHLMAYR u. LIPS, 1980).…”

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Vergleichende klinische Untersuchungen zwischen der Tranquanalgesie und der Halothan-Kombinationsnarkose bei der transurethralen Elektroresektion der Prostata

Ελευθεριάδης¹

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Die Entwicklung der Anästhesie nach 1945

Esch¹,

Goerig²

2003

50 Jahre Deutsche Gesellschaft Für Anästhesiologie Und Intensivmedizin

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Die Wirkung von Ethrane auf die Hämodynamik und die Sauerstoffversorgung des Myocards im Vergleich zu Halothane

Cited by 3 publications

References 14 publications

Effects of Enflurane on Coronary Haemodynamics in Patients with Ischaemic Heart Disease

Effects of Enflurane on Coronary Haemodynamics in Patients with Ischaemic Heart Disease

Vergleichende klinische Untersuchungen zwischen der Tranquanalgesie und der Halothan-Kombinationsnarkose bei der transurethralen Elektroresektion der Prostata

Die Entwicklung der Anästhesie nach 1945

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