Die Wirkung von Furosemid und NaCl-Belastung auf die Chloridausscheidung im Einzelnephron der Rattenniere

Malnic, Gerhard; Enokibara, Hiroko; Mm, Aires; Fl, Vieira

doi:10.1007/bf00592279

Cited by 20 publications

(3 citation statements)

References 27 publications

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“…As shown in table II, however, the TF/Pin ratio at the LPT in Group I ani mals did not differ from the value observed in this laboratory in normal hydropenic rats. This lack of inhibition of proximal tubular sodium reabsorption by furosemide is con sistent with the findings of other investigators using similar or larger doses of this agent [3,4,15], Burg et al [2], using conventio nal in vitro microperfusion techniques, were also unable to demonstrate an effect of furo semide on the proximal tubule. Lucci et al [14] have shown that the addition of 3 mM furosemide to a proximal tubular perfusate in vivo inhibited proximal reabsorption.…”

Section: Discussioncontrasting

confidence: 34%

Estimation of Superficial Nephron Pars Recta Sodium Reabsorption <i>in vivo</i>

Reineck¹

1979

Kidney Blood Press Res

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Many in vitro studies have examined the transport characteristics of the pars recta. Yet, because this nephron segment is inaccessible to direct micropuncture, its in vivo reabsorptive capacity remains unknown. In superficial nephrons, water movement between the late proximal and early distal tubule is limited to the pars recta and thin descending limb of Henle’s loop. Net water reabsorption in this latter segment is dependent on a favorable osmotic gradient generated by the hypertonic medullary interstitium. Accordingly, if this hypertonicity is abolished, net water movement between the late proximal and early distal tubule is limited to the pars recta. Since sodium reabsorption is isotonic along the pars recta, a comparison of fractional water delivery to the late proximal and early distal tubule provides an index of sodium reabsorption by this nephron segment. Therefore, furosemide was administered to 7 Munich-Wistar rats and micropuncture samples were obtained from the late proximal and early distal tubules. Ascending vasa recta (AVR) samples were also obtained and the ratio of AVR/plasma osmolality were determined and averaged 1.04, indicating that furosemide abolished medullary hypertonicity. The fractional delivery of filtrate to the late proximal tubule averaged 40.2% and that to the early distal tubule 30.0%, indicating that 10.2% of the filtered sodium was re-absorpbed along the pars recta. The administration of benzolamide, a carbonic anhydrase inhibitor, decreased this value to 5% of the filtered load.

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Section: Discussioncontrasting

confidence: 34%

Estimation of Superficial Nephron Pars Recta Sodium Reabsorption <i>in vivo</i>

Reineck¹

1979

Kidney Blood Press Res

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“…It must be added that, although the main effect of furosemide seems to be restricted to the loop of Henle, the sodium transport in the proximal tubules is also reduced, but probably without substantial decrease of the fractional reabsorption (5, 9,15,25,32,41,48). In addition to this, furosemide increases the intrarenal pressure (21,26) and also affects the magnitude (49) and possibly also the distribution (8) of the renal blood flow.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study the effect of furosemide upon patients with unilateral pyelonephritis has been investigated by the selective renal function technique. This diuretic was chosen because 1) it exerts its main effect upon a well-defined part of the nephron, the loop of Henle (5, 9,15,25,32,41,48), and 2) loss of some functions of this segment cannot be compensated for by other parts of the nephron. The obvious experimental advantages of the identical and normal milieu interieur for each pair of kidneys investigated have been discussed in detail by others (10).…”

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confidence: 99%

The Effect of Furosemide on the Function of Normal and Diseased Kidneys in Patients With Unilateral Pyelonephritis

Ofstad

1971

Journal of Internal Medicine

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Abstract. In nine patients with unilateral pyelonephritis the renal function has been measured by the split function technique before and after the i.v. injection of furosemide. Before the injection the excretion fraction of sodium and chloride as well as the diuresis, the osmotic clearance and the free water clearance per unit of glomerular filtrate were greatest, and the urinary concentration of inulin was least, in the pyelonephritic kidneys. After the injection of furosemide these differences were no longer significant. When related to the osmotic clearance, the free water clearance was reduced in all kidneys after the injection. The findings are compatible with the presence of a functioning loop of Henle in most nephrons of the pyelonephritic kidneys.

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Transport Functions of the Distal Convoluted Tubule

Costanzo

Windhager

1978

Physiology of Membrane Disorders

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Die Wirkung von Furosemid und NaCl-Belastung auf die Chloridausscheidung im Einzelnephron der Rattenniere

Cited by 20 publications

References 27 publications

Estimation of Superficial Nephron Pars Recta Sodium Reabsorption <i>in vivo</i>

Estimation of Superficial Nephron Pars Recta Sodium Reabsorption <i>in vivo</i>

The Effect of Furosemide on the Function of Normal and Diseased Kidneys in Patients With Unilateral Pyelonephritis

Transport Functions of the Distal Convoluted Tubule

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