Die Wirkung von Lithium auf serotoninerge Funktionen

Müller‐Oerlinghausen, B.

doi:10.1007/978-3-642-60819-3_5

Cited by 1 publication

(1 citation statement)

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“…Although it was postulated by Baldessarini, Tondo and Hennen (2001) that the reduction of the suicide risk by lithium prophylaxis is primarily caused by its depression-preventive effect, our hypothesis from the beginning has been that lithium differs from other mood stabilizers and also from most antidepressants by its very marked serotonin-agonistic effects which are related predominantly to its pre-synaptic functions (Müller-Oerlinghausen, 1985, 1997. It Impact of Lithium on Suicidal Behavior appears at least an attractive speculation that this serotoninergic action, possibly in connection with other effects, is related to its very well established anti-aggressive effects in animals as well as humans (Nilsson, 1993), but also to its antisuicidal effects.…”

Section: Is the Anti-suicidal And Mortality Reducingmentioning

confidence: 96%

The Impact of Lithium Long-Term Medication on Suicidal Behavior and Mortality of Bipolar Patients

Müller‐Oerlinghausen¹,

Felber²,

Berghöfer³

et al. 2005

Archives of Suicide Research

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The article reviews the existing evidence and the concept of the anti-suicidal effect of lithium long-term treatment in bipolar patients. The core studies supporting the concept of a suicide preventive effect of lithium in bipolar patients come from the international research group IGSLI, from Sweden, Italy, and recently also from the U.S. Patients on lithium possess an eight- time lower suicide risk than those off lithium. The anti-suicidal effect is not necessarily coupled to lithium's episode suppressing efficacy. The great number of lives potentially saved by lithium adds to the remarkable benefits of lithium in economical terms. The evidence that lithium can effectively reduce suicide risk has been integrated into modern algorithms in order to select the optimal maintenance therapy for an individual patient.

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Section: Is the Anti-suicidal And Mortality Reducingmentioning

confidence: 96%