Die Wirkung von Pankreozymin auf Blutzucker, immunologisch meßbares Insulin, freie Fettsäuren und Glycerin beim Menschen

Relationship between changes of serum cholecystokinin-pancreozymin and serum insulin after different stimuli

“…Thus, the ingestion of magnesium sulphate, a potent CCK-PZ releasing agent [18], had no significant effect on the level of serum insulin. In contrast, previous studies have suggested that CCK-PZ does cause insulin release in man [7,8]. The majority of these studies, however, have involved investigating the effect of relatively impure preparations of CCK-PZ on insulin release, and it seems probable that these preparations contained other active substances.…”

“…More recently, it has been established that oral glucose stimulates a greater release of insulin than the equivalent amount administered intravenously [3,4,5,6]. It has been suggested that cholecystokinin-pancreozymin (CCK-PZ) plays a role in this gastro-intestinal stimulation of insulin release in man [7,8]. In addition impure CCK-PZ preparations have been shown to enhance insulin release from the isolated perfused rat pancreas [9,10].…”

The Effect of the β‐Receptor Blockade (Propranolol) on the Endocrine and Exocrine Pancreatic Function in Man after the Administration of Intestinal Hormones (Secretin and Cholecystokinin‐Pancreozymin)

“…Secretin and cholecystokinin-pancreozymin also lead to a rise in insulin secretion, as has been shown by Dupr6 et al (1966); by Unger etal. (1967) in animals; and by Raptis et al (1968) and Schrijder et al (1968) in man. The aim of the investigations under discussion was to find out whether the effect of the intestinal hormones secretin (SC) and cholecystokinin-pancreozymin (CCK/PZ) on the endocrine and exocrine pancreatic function is dependent upon the 8-adrenergic system.…”