Die Wirkung von Pharmaka auf die Elimination von Noradrenalin aus der Perfusionsfl�ssigkeit und die Noradrenalinaufnahme in das isolierte Herz

Lindmar, R.; Muscholl, E.

doi:10.1007/bf00329896

Cited by 180 publications

(45 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The same has been shown for cocaine (Lindmar & Muscholl, 1964). By inhibiting the re-uptake of noradrenaline liberated during sympathetic nerve stimulation, all these drugs increase noradrenaline overflow into the venous effluent.…”

Section: Discussionsupporting

confidence: 67%

See 1 more Smart Citation

Interactions of inhibitors of noradrenaline uptake and angiotensin on the sympathetic nerves of the isolated rabbit heart

Schümann¹,

Starke²,

Werner³

1970

British J Pharmacology

View full text Add to dashboard Cite

Summary1. The interaction of angiotensin and several inhibitors of the uptake of noradrenaline across the neuronal membrane (cocaine, desipramine, protriptyline. and pronethalol) on the output of noradrenaline produced by sympathetic nerve stimulation has been studied in the isolated perfused rabbit heart. 2. Most of these drugs increased noradrenaline outflow angiotensin, for example, by 175x),. Cocaine (10-4M) did not change the amine overflow, probably because this very high concentration inhibited not only the re-uptake but also the liberation of noradrenaline. 3. Desipramine, protriptyline, and pronethalol, although infused in concentrations which enhanced the noradrenaline output, were not able to impair the angiotensin-induced increase of transmitter overflow. In the presence of cocaine (10-4M) the increase elicited by angiotensin was slightly reduced, though lower concentrations of cocaine, as previously described, do not interfere with the effect of angiotensin. 4. In contrast to the interaction between uptake inhibitors and angiotensin, the augmented output of noradrenaline caused by an uptake inhibitor could not be increased further by infusion of a second uptake inhibitor. 5. It is concluded that the increase of the outflow of noradrenaline during sympathetic nerve stimulation by small doses of angiotensin is not caused by an inhibition of re-uptake. On the contrary, the transmitter liberation seems to be facilitated. This is a novel principle of drug action on the sympathetic nerve terminals. IntroductionAngiotensin increases the output of noradrenaline from isolated rabbit hearts caused by stimulation of the sympathetic cardiac nerves (Starke, Werner & Schumann, 1969). This effect is not due to coronary constriction, for infusion of vasopressin or diminution of the delivery of the perfusion pump decrease, rather than augment, noradrenaline overflow (Starke, Werner, Hellerforth & Schumann.

show abstract

Section: Discussionsupporting

confidence: 67%

“…Removal is chiefly a consequence of net-uptake across the neuronal membrane (Lindmar & Muscholl, 1964). Results are presented in Table 3.…”

Section: Noradrenaline Determinationmentioning

confidence: 99%

Interactions of inhibitors of noradrenaline uptake and angiotensin on the sympathetic nerves of the isolated rabbit heart

Schümann¹,

Starke²,

Werner³

1970

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…Pretreatment with reserpine leaves the first step intact, but prevents the second (Lindmar & Muscholl, 1964). Thus, in reserpine pretreated animals, noradrenaline is transported at a normal rate, but instead of being stored in vesicles it is inactivated enzymatically by monoamine oxidase.…”

Section: Discussionmentioning

confidence: 99%

Effect of Infusion of Metaraminol on the Response of Reserpine‐pretreated Spinal Cats to Tyramine and to Noradrenaline

Bhagat

Ragland

1966

British Journal of Pharmacology and Chemotherapy

View full text Add to dashboard Cite

“…He suggested that cocaine, as well as preventing uptake of noradrenaline, also prevented release of noradrenaline from the tissue stores by tyramine. Many of the /8-adrenoreceptor blocking drugs, including pronethalol, propranolol and dichloroisoprenaline, have been shown to act like cocaine in decreasing the uptake of noradrenaline by the heart and other tissues (Farrant, Harvey & Pennefather, 1964;Lindmar & Muscholl, 1964;Iversen, 1965;von Euler, 1966). This raises the possibility that there may be two components in the action of these drugs in preventing the action of tyramine on the heart; they may reduce the release of noradrenaline by tyramine, in addition to antagonizing the effects of the released noradrenaline.…”

mentioning

confidence: 99%

The effects of some β‐adrenoreceptor blocking drugs on the uptake and release of noradrenaline by the heart

Foo¹,

Jowett²,

Stafford³

1968

British J Pharmacology

View full text Add to dashboard Cite

The potencies of some β‐adrenoreceptor blocking drugs in reducing noradrenaline uptake by the isolated heart were compared with their potencies in reducing the release of noradrenaline from the heart by tyramine. Of the drugs tested, propranolol, pronethalol and dichloroisoprenaline were the most potent in blocking uptake and release of noradrenaline, although none was at potent as cocaine; MJ 1999 and I.C.I. 50172 were only weakly effective. Pronethalol and dichloroisoprenaline each reduced release of noradrenaline by tyramine in the concentration range (10−7–10−6M) where blockade of responses to tyramine was apparent; with these drugs both reduction of noradrenaline release and β‐receptor blockade contribute to the reduction in responses to tyramine. Potency of β‐receptor blocking drugs in reducing noradrenaline uptake is unrelated to potency in blocking β‐receptors; Kö 592 blocks β‐receptors without affecting noradrenaline uptake.

show abstract

Die Wirkung von Pharmaka auf die Elimination von Noradrenalin aus der Perfusionsfl�ssigkeit und die Noradrenalinaufnahme in das isolierte Herz

Cited by 180 publications

References 21 publications

Interactions of inhibitors of noradrenaline uptake and angiotensin on the sympathetic nerves of the isolated rabbit heart

Interactions of inhibitors of noradrenaline uptake and angiotensin on the sympathetic nerves of the isolated rabbit heart

Effect of Infusion of Metaraminol on the Response of Reserpine‐pretreated Spinal Cats to Tyramine and to Noradrenaline

The effects of some β‐adrenoreceptor blocking drugs on the uptake and release of noradrenaline by the heart

Contact Info

Product

Resources

About