Die Zahl argentaffiner Zellen des menschlichen Verdauungstraktes unter normalen und pathologischen Bedingungen

Funk, H.; Weber, Edward C.; Hedinger, Chr.; Hardmeier, T

doi:10.1007/bf02438762

Cited by 10 publications

(3 citation statements)

References 10 publications

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“…The enteroendocrine cells form a heterogeneous population throughout the gastrointestinal tract, producing a variety of different polypeptide hormones, and showing varying degrees of affinity for silver salts (Cristina et al 1978, Solcia et al 1982. Published data indicate an average of two argentaffin and two non-argentaffin enteroendocrine cells per crypt in the normal human colon (Deschner 1965, Funk et al 1966, Cristina et al 1978. We have studied the argyrophil cell population in rectums removed for diverticular disease and carcinoma, and found an average of four to five argyrophil cells per crypt (unpublished data).…”

Section: Discussionmentioning

confidence: 99%

Enteroendocrine cell hyperplasia, carcinoid tumours and adenocarcinoma in long‐standing ulcerative colitis

et al. 1986

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Chronic ulcerative colitis may be accompanied by a variety of epithelial changes, including loss of goblet cells, Paneth cell metaplasia, villous metaplasia, and dysplasia. Total colitis is also accompanied by an increased incidence of adenocarcinoma. All these changes are assumed to be secondary to repeated mucosal damage, but how they develop is unknown. Little attention has been paid to the enteroendocrine cell population, despite the postulated role of these cells as producers of trophic hormones. We describe two patients with long-standing ulcerative colitis who developed both adenocarcinoma and carcinoid tumours. In both, there were increased numbers of enteroendocrine cells in the uninvolved colonic mucosa. We suggest that an increased enteroendocrine cell mass may be part of a non-specific reaction to chronic mucosal injury, and by producing an elevated level of trophic hormones may act as a promoter in the development of neoplasia.

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Section: Discussionmentioning

confidence: 99%

Enteroendocrine cell hyperplasia, carcinoid tumours and adenocarcinoma in long‐standing ulcerative colitis

et al. 1986

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“…In the duodenal mucosa, the number of Grimelins-positive cells is given as the number found in 100 completely and perpendicularly sectioned crypts as proposed by Funk et al [6].…”

Section: Methodsmentioning

confidence: 99%

Untersuchungen zur Inselzell-Regeneration, Hyperplasie und zu intrainsul�ren zellul�ren Beziehungen wahrend eines Langzeit-Streptozotocin-Diabetes bei Ratten

et al. 1970

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Studies on islet cell regeneration, hyperplasia and intrainsular cellular interrelations in long.lasting streptozotocin diabetes in ratsSummary. Diabetes was induced in rats with various single i.v. doses of streptozotocin. The rats were killed 4--10 months thereafter. Marked hyperglycaemia, ketonaemia and a rise of plasma free fatty acids resulted. The weight increase was markedly reduced. There was a clear reciprocal correlation between the injected dose of the diabetogenic agent and plasma IRI. The same was true for the B-cell counts. There was a marked B-cell hypertrophy, whereas we found only slight indication for B-cell regeneration. In one animal a functioning B-cell adenoma developed and almost all the parameters tested were normalized. In the diabetic animals the Ae-eells were predominant in the islets of Langerhans and their mean nuclear diameters were increased. In the duodenal nmeosa no increase in the number of glucagonoeytes was found.We interpret this activity of the glueagonoeytes as a consequence of permanent and long-lasting hyperglyeaemia. Investigations sur la regdndration et l'hyperplasie des cellules dans les ilots de Langerhans et sur les interrelations cellulaires intrainsulaires dans le diab~te de longue durde provoqud par la streptozotocine chez le ratRdsumd. Par des doses diffgrentes de Streptozotocine i.v. on provoque chez des rats un diab6te d'une durde de 4 ~ 10 tools. On note une hyperglyc6mie sdv~re, une ac6ton@mie et une augmentation moddr6e des acides gras. La prise de poids est diminude de fagon marqude. --I1 existe une nette eorrdlation rdeiproque entre la quantitd d'agent diab@tog~ne injeetd et l'insuline immunordactive plasmatique (IRI). On trouve le m@me rapport entre le nombre des cellules Bet Ia quantitd de Streptozotocine. On note unc eorrdlation direete entre le nombre des eellules Bet I'IRI. --L'hypertrophie des eellules B est importante alors qu'on ne trouve que pea de signes de r@gdndration des ilots et des eellules B. --Chez un des rats on note l'apparition d'un addnome ~ cellules B fonctionnant, provoquant une normalisation du m6tabolisme glueidique. --Chez les animaux diabdtiques, les cellules A 2 prgdominent et le diam~tre moyen des noyaux est augment6. On ne note pas d'augmentation signifieative des glueagonoeytes de la muqueuse duod6nale.Nous consid@rons que eette augmentation de l'aetivit@ des glucagonoeytes est fonction de l'hyperglyedmie perm~nente et de longue durge.

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“…Carcinoid tumors are derived from argentaffin or Kulchitsky cells, which arise from neuroectoderm [ 1 , 2 ] . These APUD cells (amine precursor uptake and decarboxylation), which have the ability to synthesize polypeptide products, migrate during fetal development and are most frequently found in the gastrointestinal tract, where their numbers vary according to age and disease condition [3]. The most common primary sites for carcinoid tumors are the appendix, bronchus, ileum, and rectum [4].…”

Section: Introductionmentioning

confidence: 99%

Malignant carcinoid of the gallbladder: Third reported case and review of the literature

Bosl

Yagoda

Câmara-Lopes

1980

Journal of Surgical Oncology

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Die Zahl argentaffiner Zellen des menschlichen Verdauungstraktes unter normalen und pathologischen Bedingungen

Cited by 10 publications

References 10 publications

Enteroendocrine cell hyperplasia, carcinoid tumours and adenocarcinoma in long‐standing ulcerative colitis

Enteroendocrine cell hyperplasia, carcinoid tumours and adenocarcinoma in long‐standing ulcerative colitis

Untersuchungen zur Inselzell-Regeneration, Hyperplasie und zu intrainsul�ren zellul�ren Beziehungen wahrend eines Langzeit-Streptozotocin-Diabetes bei Ratten

Malignant carcinoid of the gallbladder: Third reported case and review of the literature

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