Die Zuckerkrankheit und ihre Behandlung

Diabetic autonomic neuropathy

“…Before 1900 and in the early part of this century there were occasional references to clinical features now attributed to diabetic autonomic neuropathy including those of De Calvi [9] on neurogenic bladder disturbance, Pavy [10] on abnormal sweating, Buzzard [11], Auch~ [12] and Pryce [13] on vasomotor disturbance, Pitres [14] on loss of testicular sensation and absence of pupillary reflexes, and Naunyn [15] and Von Noorden [16] on impotence. Diabetic autonomic neuropathy as an entity, however, only became generally recognised following the reviews by Jordan in 1936 [17] and Rundles in 1945 [181. Although the autonomic nervous system is usually regarded as an efferent system innervating smooth muscle of hollow viscera and arterioles as well as certain exocrine and endocrine tissue, it is helpful to include the accompanying visceral afferent sensory fibres.…”

Physical exercise and fuel homeostasis in diabetes mellitus

“…A beneficial effect on the clinical course of this disease has in fact been recognized since ancient times [1]. Before the advent of insulin, however, evidence had accumulated to the effect that in severely diabetic patients, exercise resulted in more pronounced hyperglyCaemia, hyperketonaemia and glycosuria; in fact strenuous exertion occasionally led to coma [2,3,4]. After the introduction of insulin, it soon became apparent that in diabetics treated with insulin, blood glucose levels fell during exercise and that regular exercise reduced the exogenous insulin requirement [5,6,7,8].…”