Dieckol inhibits non‐small–cell lung cancer cell proliferation and migration by regulating the PI3K/AKT signaling pathway

Wang, Chun‐Hong; Li, Xiaofeng; Jin, Lifang; Zhao, Yan; Zhu, Gengjun; Shen, Wenlong

doi:10.1002/jbt.22346

Cited by 45 publications

(41 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An in vitro study performed by Wang et al has shown that this substance has anticancer properties; in particular it acts by inhibiting the invasive and migratory properties of A549 cells and also by inducing apoptosis through inhibition of PI3K/AKT/mTOR signaling, activating the E-cadherin tumor suppressor protein. This suggests that dieckol may be a potent natural anticancer drug for the treatment of NSCLC (56). These data confirm the potential complementary role of RES, CUR and EGCG in cancer treatment to enhance the efficacy of existing therapies, reducing side-effects.…”

Section: Lung Cancersupporting

confidence: 65%

Polyphenols in cancer prevention: New insights (Review)

et al. 2020

View full text Add to dashboard Cite

A huge volume of literature data suggests that a diet rich in fruits and vegetables, mostly due to the contribution of natural polyphenols, could reduce the incidence of specific cancers. Resveratrol, epigallocatechin gallate and curcumin are among the most extensively studied polyphenols: The majority of the effects attributed to these compounds are linked to their antioxidant and anti-inflammatory properties. The multiple mechanisms involved include the modulation of molecular events and signaling pathways associated with cell survival, proliferation, differentiation, migration, angiogenesis, hormonal activities, detoxification enzymes and immune responses. Notwithstanding their promising role in cancer prevention and treatment, polyphenols often have a poor bioavailability when administered as pure active principles, representing an important limit to their use. However, the bioavailability and thus the efficacy of these compounds can be improved by their administration in combination with other phytochemicals, with anticancer drugs or in polyphenol-loaded nanotechnology-based delivery systems. The possibility of combining conventional drugs with polyphenols offers very valuable advantages, such as the building of more efficient anticancer therapies with less side-effects on the health of patients. The present review focuses on current knowledge regarding the interactions between natural polyphenols and cancer development in order to gain a clearer comprehension of the potential mechanisms through which individual foods and food components may be exploited to reduce cancer risk. Contents 1. Introduction 2. Literature search 3. Classification of polyphenols 4. Prostate cancer 5. Colon cancer 6. Breast cancer 7. Lung cancer 8. Bladder cancer 9. Skin cancer 10. Pancreatic cancer 11. Leukemia 12. Conclusion

show abstract

Section: Lung Cancersupporting

confidence: 65%

Polyphenols in cancer prevention: New insights (Review)

et al. 2020

View full text Add to dashboard Cite

show abstract

“…These properties are mainly against breast cancer cell lines MCF-7 and MDA-MB-231, SKOV-3 (ovarian cancer line), HeLa (cervical cancer cell line), HT1080 (fibrosarcoma cancer cell line), A549 (adenocarcinomic human alveolar basal epithelial cell), and HT-29 (human colon cancer cell line) [196][197][198][199][200]. The dieckol demonstrated a high anticancer activity against the non-small-cell lung cancer line A549 [201]. Eckol inhibited the proliferation of SW1990 pancreatic cells induced by Reg3A (a pancreatic inflammation upregulated protein with pro-growth function) [202].…”

Section: Phlorotanninsmentioning

confidence: 99%

Seaweed Phenolics: From Extraction to Applications

et al. 2020

View full text Add to dashboard Cite

Seaweeds have attracted high interest in recent years due to their chemical and bioactive properties to find new molecules with valuable applications for humankind. Phenolic compounds are the group of metabolites with the most structural variation and the highest content in seaweeds. The most researched seaweed polyphenol class is the phlorotannins, which are specifically synthesized by brown seaweeds, but there are other polyphenolic compounds, such as bromophenols, flavonoids, phenolic terpenoids, and mycosporine-like amino acids. The compounds already discovered and characterized demonstrate a full range of bioactivities and potential future applications in various industrial sectors. This review focuses on the extraction, purification, and future applications of seaweed phenolic compounds based on the bioactive properties described in the literature. It also intends to provide a comprehensive insight into the phenolic compounds in seaweed.

show abstract

“…Dieckol is abundantly isolated from the brown alga Ecklonia cava found on Jeju Island, Korea [ 13 ]. Dieckol has been reported to possess various biological properties such as anti-cancer, antithrombic and profibrinolytic activities, hepatoprotective, antioxidant, anti-diabetic, anti-hyperlipidemic, photochemopreventive, and anti-HIV [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Interestingly, Dieckol isolated from brown algae Ecklonia cava has been reported to possess inhibitory activity against 3CLpro or Mpro of SARS-CoV [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

Dieckol and Its Derivatives as Potential Inhibitors of SARS-CoV-2 Spike Protein (UK Strain: VUI 202012/01): A Computational Study

et al. 2021

View full text Add to dashboard Cite

The high risk of morbidity and mortality associated with SARS-CoV-2 has accelerated the development of many potential vaccines. However, these vaccines are designed against SARS-CoV-2 isolated in Wuhan, China, and thereby may not be effective against other SARS-CoV-2 variants such as the United Kingdom variant (VUI-202012/01). The UK SARS-CoV-2 variant possesses D614G mutation in the Spike protein, which impart it a high rate of infection. Therefore, newer strategies are warranted to design novel vaccines and drug candidates specifically designed against the mutated forms of SARS-CoV-2. One such strategy is to target ACE2 (angiotensin-converting enzyme2)–Spike protein RBD (receptor binding domain) interaction. Here, we generated a homology model of Spike protein RBD of SARS-CoV-2 UK strain and screened a marine seaweed database employing different computational approaches. On the basis of high-throughput virtual screening, standard precision, and extra precision molecular docking, we identified BE011 (Dieckol) as the most potent compounds against RBD. However, Dieckol did not display drug-like properties, and thus different derivatives of it were generated in silico and evaluated for binding potential and drug-like properties. One Dieckol derivative (DK07) displayed good binding affinity for RBD along with acceptable physicochemical, pharmacokinetic, drug-likeness, and ADMET properties. Analysis of the RBD–DK07 interaction suggested the formation of hydrogen bonds, electrostatic interactions, and hydrophobic interactions with key residues mediating the ACE2–RBD interaction. Molecular dynamics simulation confirmed the stability of the RBD–DK07 complex. Free energy calculations suggested the primary role of electrostatic and Van der Waals’ interaction in stabilizing the RBD–DK07 complex. Thus, DK07 may be developed as a potential inhibitor of the RBD–ACE2 interaction. However, these results warrant further validation by in vitro and in vivo studies.

show abstract

Dieckol inhibits non‐small–cell lung cancer cell proliferation and migration by regulating the PI3K/AKT signaling pathway

Cited by 45 publications

References 44 publications

Polyphenols in cancer prevention: New insights (Review)

Polyphenols in cancer prevention: New insights (Review)

Seaweed Phenolics: From Extraction to Applications

Dieckol and Its Derivatives as Potential Inhibitors of SARS-CoV-2 Spike Protein (UK Strain: VUI 202012/01): A Computational Study

Contact Info

Product

Resources

About