Dielectric barrier discharge plasma treatment of modified SU-8 for biosensing applications

Ramirez, Jhonattan C.; Schianti, Juliana N.; Souto, Dênio Emanuel Pires; Kubota, Lauro T.; Hernandez-Figueroa, Hugo E.; Gabrielli, Lucas H.

doi:10.1364/boe.9.002168

Cited by 14 publications

(16 citation statements)

References 33 publications

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“…The possibility of thermal modification of the refractive index of the SU-8 layers was shown in [36]. Nowadays, research aims at reducing the hydrophobicity of the polymer surface [37]. There is a possibility of direct laser writing on the SU-8 layer, yielding low-loss waveguide structures [38].…”

Section: Materials and Interferometer Systemmentioning

confidence: 99%

Study of a Broadband Difference Interferometer Based on Low-Cost Polymer Slab Waveguides

Gut

2019

Nanomaterials

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A model and the waveguide parameters of a broadband, polymer-based slab waveguide difference interferometer is presented in this paper. The parameters were determined based on knowledge of the dispersion in the structure materials used to fabricate the waveguide. The impact of the waveguide layer thickness, propagation path length, and change in the waveguide cover refractive index on the output signal from the system was determined. It has been shown that the direction of the maximum shifting is determined by the thickness of the waveguide layer. A relationship describing the shift in the signal extrema for a change in the waveguide cover refractive index was derived. The results show that the use of a propagation constant simplifies the description of the interferometer. Polymer waveguides, although they have a small contrast in refractive indices, allow for large shifts in the maxima of the signal. The determined shifts in the output signal extrema for polymer waveguides are comparable, and these shifts are larger for some waveguide thicknesses compared to waveguides based on Si3N4.

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Section: Materials and Interferometer Systemmentioning

confidence: 99%

Study of a Broadband Difference Interferometer Based on Low-Cost Polymer Slab Waveguides

Gut

2019

Nanomaterials

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“…Therefore, devices based on polymeric materials are presented as a viable alternative, which despite having very low refractive indices and having shown low sensitivity, efforts are made by the scientific community to improve this scenario, compensating for the unfavorable optical characteristics of the material, with an efficient and reliable design [31][32][33]; our proposal goes in this direction. On the other hand, characteristics such as the biocompatibility of these materials enable simpler and more durable biofunctionalization processes, and its low production cost provides conditions for these devices to be massively produced for single-use [34], these are points to keep in mind when justifying its implementation.…”

Section: Introductionmentioning

confidence: 99%

Electro-Optical Biosensor Based on Embedded Double-Monolayer of Graphene Capacitor in Polymer Technology

et al. 2021

Self Cite

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In this work, we present an interferometric polymer-based electro-optical device, integrated with an embedded double-monolayer graphene capacitor for biosensing applications. An external voltage across the capacitor applies an electric field to the graphene layers modifying their surface charge density and the Fermi level position in these layers. This in turn changes the electro-optic properties of the graphene layers making absorption in the waveguide tunable with external voltages. Simultaneously, it is possible to appreciate that this phenomenon contributes to the maximization of the light-graphene interaction by evanescent wave in the sensing area. As a result, it is obtained large phase changes at the output of the interferometer, as a function of small variations in the refractive index in the cladding area, which significantly increasing the sensitivity of the device. The optimum interaction length obtained was 1.24 cm considering a cladding refractive index of 1.33. An absorption change of 129 dB/mm was demonstrated. This result combined with the photonic device based on polymer technology may enable a low-cost solution for biosensing applications in Point of Care (PoC) platform.

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“…The SU-8 epoxy polymer is one such material that has great potential for fabrication of high aspect ratio of micro/nanostructured scaffolds for lab-on-a-chip devices [1][2][3][4]. In particular, SU-8 has been used as an impressive platform for the development of various smart biomedical devices including biosensors [5][6][7], bacterial diagnosis [8][9][10], cantilever [11], bioelectrodes [12] and microrobots [13,14] owing to its excellent optical and mechanical properties with chemical stability even against acids [3,15,16]. Moreover, SU-8 nanostructures with tunable high aspect ratios have been fabricated and used for eukaryote cell interface and for simultaneous visualization of the traction force and focal adhesion of eukaryotic cells [17].…”

Section: Introductionmentioning

confidence: 99%

“…Whilst the SU-8 properties combined with its biocompatibility facilitates its application in bio-related material interfaces [6][7][8][9]17,18], how the surface properties of SU-8 affect bacterial adhesion and successive proliferation is poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Physiochemically distinct SU-8 surfaces tailor Xylella fastidiosa cell-surface holdfast and colonization

Anbumani

Silva

Alaferdov

et al. 2021

Preprint

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SU-8 polymer is an excellent platform for diverse applications due to its high aspect ratio of micro/nanostructures fabrication and exceptional optical, chemical, and biocompatible properties. Although SU-8 has been often investigated for a variety of biological applications, how its surface properties influence both the interaction of bacterial cells with the substrate and its colonization is poorly understood. In this work, we tailor SU-8 nanoscale surface properties to investigate single cell motility, adhesion and successive colonization of a phytopathogenic bacteria, Xylella fastidiosa. Different surface properties of SU-8 thin films have been prepared using photolithography processing and oxygen plasma treatment. We found a significant difference in bacterial cell behavior and subsequent colonization on SU-8 as surface property changes. A larger density of carboxyl groups in hydrophilic plasma-treated SU-8 surfaces promotes faster cell motility in the earlier stage of the growth. The hydrophobic nature of pristine SU-8 surfaces has no trackable bacterial motility with 5 to 10 times more single cells adhered to surface than its plasma-treated counterpart. In fact, plasma-treated SU-8 samples suppressed bacterial adhesion, with surfaces showing less than 5% coverage. These results not only showcase that SU-8 surface properties can impact the bacterial behavior in a spatiotemporal manner, but also provide insights on the prominent ability of pathogens to evolve and adapt to different surface properties.

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Dielectric barrier discharge plasma treatment of modified SU-8 for biosensing applications

Cited by 14 publications

References 33 publications

Study of a Broadband Difference Interferometer Based on Low-Cost Polymer Slab Waveguides

Study of a Broadband Difference Interferometer Based on Low-Cost Polymer Slab Waveguides

Electro-Optical Biosensor Based on Embedded Double-Monolayer of Graphene Capacitor in Polymer Technology

Physiochemically distinct SU-8 surfaces tailor Xylella fastidiosa cell-surface holdfast and colonization

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