Dielectric Characterization Improvement of Biopsy Samples Via a Coated Open-Ended Coaxial Probe

Canicattì, Eliana; Fontana, Nunzia; Barmada, Sami; Monorchio, Agostino

doi:10.1109/mms55062.2022.9825517

Cited by 8 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, the probe was specifically designed to reduce radiation losses. As a result, the occurrence of the fringing field effect in air can be avoided, allowing for optimal electric field confinement [ 41 ]. Consequently, the measurement of the reflection coefficient becomes more accurate, leading to improved reconstruction of the dielectric properties.…”

Section: Resultsmentioning

confidence: 99%

“…To ensure accurate measurements, the coaxial probe was slightly pressed against the tissue samples, applying a controlled pressure to eliminate any air gap between the probe tip and the tissue, since it may adversely affect the measurements [ 18 ]. It has been observed in previous studies that the curvature radius affects the coupling between the probe and the tip, leading to inaccuracies in the reconstruction of the dielectric parameters [ 40 , 41 , 42 ]. However, by maintaining a minimal insertion depth of 0.3 mm, it is possible to achieve high precision and accuracy in the dielectric characterization of both healthy and malignant breast tissue using the presented probe.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Dielectric Characterization of Breast Biopsied Tissues as Pre-Pathological Aid in Early Cancer Detection: A Blinded Feasibility Study

Canicattì,

Sánchez-Bayuela,

Romero Castellano

et al. 2023

Diagnostics

Self Cite

View full text Add to dashboard Cite

Dielectric characterization has significant potential in several medical applications, providing valuable insights into the electromagnetic properties of biological tissues for disease diagnosis, treatment planning, and monitoring of therapeutic interventions. This work presents the use of a custom-designed electromagnetic characterization system, based on an open-ended coaxial probe, for discriminating between benign and malignant breast tissues in a clinical setting. The probe’s development involved a well-balanced compromise between physical feasibility and its combined use with a reconstruction algorithm known as the virtual transmission line model (VTLM). Immediately following the biopsy procedure, the dielectric properties of the breast tissues were reconstructed, enabling tissue discrimination based on a rule-of-thumb using the obtained dielectric parameters. A comparative analysis was then performed by analyzing the outcomes of the dielectric investigation with respect to conventional histological results. The experimental procedure took place at Complejo Hospitalario Universitario de Toledo—Hospital Virgen de la Salud, Spain, where excised breast tissues were collected and subsequently analyzed using the dielectric characterization system. A comprehensive statistical evaluation of the probe’s performance was carried out, obtaining a sensitivity, specificity, and accuracy of 81.6%, 61.5%, and 73.4%, respectively, compared to conventional histological assessment, considered as the gold standard in this investigation.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Dielectric Characterization of Breast Biopsied Tissues as Pre-Pathological Aid in Early Cancer Detection: A Blinded Feasibility Study

Canicattì,

Sánchez-Bayuela,

Romero Castellano

et al. 2023

Diagnostics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Initial evaluations indicated a minimum detectable spherical sample size of approximately 4 mm in diameter [29,30]. However, considering that biopsy tissues often have a cylindrical shape, we demonstrated the successful characterization of cylindrical biopsy samples measuring 2 mm (12 G) in diameter, achieving a reconstruction error of less than 9% in determining dielectric properties [31]. Nevertheless, when dealing with specimens of 1.8 mm (13 G) in diameter, we encountered a significant challenge, experiencing a reconstruction error exceeding 15% due to electric field dispersion.…”

Section: Introductionmentioning

confidence: 86%

“…To prevent or reduce this phenomenon and, hence, to increase the accuracy of the electromagnetic characterization of millimeter-sized biopsy specimens, our previous work suggested a solution that confines the fringe fields to the region between the probe tip and material interface [31]. To this aim, we have designed a properly coated system.…”

Section: Coated Open-ended Coaxial Probementioning

confidence: 99%

See 1 more Smart Citation

Open-Ended Coaxial Probe for Effective Reconstruction of Biopsy-Excised Tissues’ Dielectric Properties

Canicattì,

Fontana,

Barmada

et al. 2024

Sensors

Self Cite

View full text Add to dashboard Cite

Dielectric characterization is extremely promising in medical contexts because it offers insights into the electromagnetic properties of biological tissues for the diagnosis of tumor diseases. This study introduces a promising approach to improve accuracy in the dielectric characterization of millimeter-sized biopsies based on the use of a customized electromagnetic characterization system by adopting a coated open-ended coaxial probe. Our approach aims to accelerate biopsy analysis without sample manipulation. Through comprehensive numerical simulations and experiments, we evaluated the effectiveness of a metal-coating system in comparison to a dielectric coating with the aim for replicating a real scenario: the use of a needle biopsy core with the tissue inside. The numerical analyses highlighted a substantial improvement in the reconstruction of the dielectric properties, particularly in managing the electric field distribution and mitigating fringing field effects. Experimental validation using bovine liver samples revealed highly accurate measurements, particularly in the real part of the permittivity, showing errors lower than 1% compared to the existing literature data. These results represent a significant advancement for the dielectric characterization of biopsy specimens in a rapid, precise, and non-invasive manner. This study underscores the robustness and reliability of our innovative approach, demonstrating the convergence of numerical analyses and empirical validation.

show abstract

Design and characterization of a broadband PCB-based coaxial sensor for permittivity screening in skin cancer detection applications

Fritiss,

Poulichet,

Takhedmit

et al. 2023

Meas. Sci. Technol.

View full text Add to dashboard Cite

Broadband dielectric spectroscopy is nowadays considered as a useful non-destructive diagnostic tool for biomedical applications like glucose monitoring, hydration level measurement, and cancer tissue examination. Depending on their composition and physiological state, biological tissues have different dielectric characteristics and studies on melanoma have revealed that the lesion site's skin permittivity degree changes depending on the malignancy of the lesion. The complex permittivity of suspicious areas must therefore be imaged with spatial resolution consistent with the small dimensions of these surfaces in order to correctly detect and characterize the lesion site. The variety of skin qualities for various individuals and physiological situations (such as temperature, humidity), however, makes it difficult to build a sensitive sensor capable of constantly detecting minor fluctuations in permittivity. In order to identify various types of cancers in their early stages with a good agreement between simulated and measured results, this work proposes the design of a unique microwave sensor that can precisely detect alterations in cutaneous permittivity between 1 and 6 GHz.

show abstract

Dielectric Characterization Improvement of Biopsy Samples Via a Coated Open-Ended Coaxial Probe

Cited by 8 publications

References 12 publications

Dielectric Characterization of Breast Biopsied Tissues as Pre-Pathological Aid in Early Cancer Detection: A Blinded Feasibility Study

Dielectric Characterization of Breast Biopsied Tissues as Pre-Pathological Aid in Early Cancer Detection: A Blinded Feasibility Study

Open-Ended Coaxial Probe for Effective Reconstruction of Biopsy-Excised Tissues’ Dielectric Properties

Design and characterization of a broadband PCB-based coaxial sensor for permittivity screening in skin cancer detection applications

Contact Info

Product

Resources

About