Dielectric characterization of healthy and malignant colon tissues in the 0.5–18 GHz frequency band

Fornés-Leal, Alejandro; Garcia-Pardo, Concepción; Frasson, Matteo; Beltrán, Vicente Pons; Cardona, Narcís

doi:10.1088/0031-9155/61/20/7334

Cited by 36 publications

(31 citation statements)

References 38 publications

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“…In addition, over the whole frequency band tested, the standard deviation of the dielectric constant of metastatic LNs is lower than that of normal LNs, as indicated by the error bars. This effect is similar to that reported by O'Rourke et al [] in the liver and Fornesleal et al [] in colon tissues. Figure b shows a distinct variation in the conductivities between normal and metastatic LN samples.…”

Section: Discussionsupporting

confidence: 92%

Dielectric Properties of Normal and Metastatic Lymph Nodes Ex Vivo From Lung Cancer Surgeries

Sun

Cai

et al. 2020

Bioelectromagnetics

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The dielectric properties of normal and tumor human tissues have been widely reported in recent years. However, the dielectric properties of intrathoracic lymph nodes (LNs) have not been reported. In this communication, we measured the dielectric properties (i.e., permittivity and conductivity) of ex vivo intrathoracic LNs obtained from lung cancer surgeries. Results show that the permittivity and conductivity of metastatic LNs are higher than those of normal LNs over the frequency range of 1 MHz-4 GHz. Statistically significant differences are observed at single specific frequencies (64, 128, 298, 433, and 915 MHz and 2.45 GHz). Our study provides the basic data to support future-related research and fills the research gap on the dielectric properties of LNs in the lungs. Bioelectromagnetics. 2020;41:148-155.

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Section: Discussionsupporting

confidence: 92%

Dielectric Properties of Normal and Metastatic Lymph Nodes Ex Vivo From Lung Cancer Surgeries

Sun

Cai

et al. 2020

Bioelectromagnetics

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“…The variability observed in some cases in our findings suggest, at the same time, that further studies should be applied with the aim of establishing a standard protocol, to exploit the sensitivity of the method and determine specific quantified thresholds for each pathogenic state usually synonymous with high genomic instability. Earlier dielectric studies on human breast and colon normal and malignant tissues, at much higher frequencies, though, suggest an increase of conductivity in the malignant state [50,51]. Although we also detected a similar trend with our prostate samples (liquid biopsies), this is not verified for our lung samples, probably due to different tissue structures and/or tissue acquisition conditions.…”

Section: Discussionsupporting

confidence: 51%

Applying Broadband Dielectric Spectroscopy (BDS) for the Biophysical Characterization of Mammalian Tissues under a Variety of Cellular Stresses

Souli

Klonos

Fragopoulou

et al. 2017

IJMS

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The dielectric properties of biological tissues can contribute non-invasively to a better characterization and understanding of the structural properties and physiology of living organisms. The question we asked, is whether these induced changes are effected by an endogenous or exogenous cellular stress, and can they be detected non-invasively in the form of a dielectric response, e.g., an AC conductivity switch in the broadband frequency spectrum. This study constitutes the first methodological approach for the detection of environmental stress-induced damage in mammalian tissues by the means of broadband dielectric spectroscopy (BDS) at the frequencies of 1–106 Hz. Firstly, we used non-ionizing (NIR) and ionizing radiation (IR) as a typical environmental stress. Specifically, rats were exposed to either digital enhanced cordless telecommunication (DECT) radio frequency electromagnetic radiation or to γ-radiation, respectively. The other type of stress, characterized usually by high genomic instability, was the pathophysiological state of human cancer (lung and prostate). Analyzing the results of isothermal dielectric measurements provided information on the tissues’ water fraction. In most cases, our methodology proved sufficient in detecting structural changes, especially in the case of IR and malignancy. Useful specific dielectric response patterns are detected and correlated with each type of stress. Our results point towards the development of a dielectric-based methodology for better understanding and, in a relatively invasive way, the biological and structural changes effected by radiation and developing lung or prostate cancer often associated with genomic instability.

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“…There are several studies in which the electromagnetic properties of body tissues in UWB (or at least part of this band) are addressed. Measurements were performed on different frequency bands and tissues of specimens such as cats [53], sheep [30], rats [51], [54], [55], rabbits [56], cows [57], [58], dogs [59]- [61], frogs [62], swine [63], [64], mice [65], [66] and humans [52], [67]- [69]. However, these works were performed at ex vivo conditions, i.e., samples were analyzed some minutes or even hours after extraction.…”

Section: Characterization Of Body Tissuesmentioning

confidence: 99%

“…Some of these studies aim at investigating the difference between healthy and malignant tissues for cancer diagnosis or for improving medical applications like hyperthermia and medical imaging rather than propagation issues. For instance, the Institute of Telecommunications and Multimedia Applications (iTEAM) of the Universitat Politècnica de València has conducted a measurement campaign jointly with the Hospital Universitari i Politècnic La Fe de Valencia, with the aim of studying the differences in permittivity between healthy and malignant human colon tissue [52]. In this study, healthy and cancerous colon samples from 20 human patients were characterized.…”

Section: Characterization Of Body Tissuesmentioning

confidence: 99%

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Ultrawideband Technology for Medical In-Body Sensor Networks: An Overview of the Human Body as a Propagation Medium, Phantoms, and Approaches for Propagation Analysis

Garcia-Pardo

Andreu

Fornés-Leal

et al. 2018

IEEE Antennas Propag. Mag.

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In-body sensor networks are those networks where at least one of the sensors is located inside the human body. Such wireless in-body sensors are mainly used for medical applications, collecting and monitoring important parameters for health and diseases treatment. The IEEE Standard 802.15.6-2012 for Wireless Body Area Networks (WBAN) considers in-body communications in the Medical Implant Communication Service (MICS) band. Nevertheless, high data rate communications are not feasible at the MICS band due to its narrow occupied bandwidth. In this framework, Ultra-Wideband (UWB) systems have emerged as a potential solution for in-body high data rate communications, due to its miniaturization capabilities or low power consumption. In the last years, some open issues have determined the research about in-body propagation. Firstly, the propagation medium, i.e., the human body tissues, is frequencydependent and exhibits a large attenuation at UWB frequencies. Secondly, the behavior of the in-body antennas is highly dominated by the surrounding tissues. Thus, the in-body channel characterization in UWB depends not only on the channel behavior itself, but also on the methodology of characterization. This paper intends to outline the research performed in the field of UWB in-body radio channel characterization considering the propagation medium, as well as the methodology of analysissoftware simulations, phantom measurements, in vivo measurements-. Thus, authors provide an overall perspective of the current state of the art, limitations for the analysis of in-body propagation, and future perspectives for UWB in-body channel analysis.

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Dielectric characterization of healthy and malignant colon tissues in the 0.5–18 GHz frequency band

Cited by 36 publications

References 38 publications

Dielectric Properties of Normal and Metastatic Lymph Nodes Ex Vivo From Lung Cancer Surgeries

Dielectric Properties of Normal and Metastatic Lymph Nodes Ex Vivo From Lung Cancer Surgeries

Applying Broadband Dielectric Spectroscopy (BDS) for the Biophysical Characterization of Mammalian Tissues under a Variety of Cellular Stresses

Ultrawideband Technology for Medical In-Body Sensor Networks: An Overview of the Human Body as a Propagation Medium, Phantoms, and Approaches for Propagation Analysis

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