Dielectric constant and resistivity of epidermal stratum corneum

Yamamoto, Takenobu; Yamamoto, Y.

doi:10.1007/bf02478045

Cited by 85 publications

(64 citation statements)

References 2 publications

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“…Exactly how tissue conductivities change with electric field is another unknown or poorly known parameter. By using our own experiments and literature data [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] , we set the initial and the permeabilized conductivity values of the tissues in both models as given in Table 1.…”

Section: Numerical Models -The Electroporation Processmentioning

confidence: 99%

Numerical modeling in electroporation-based biomedical applications

Pavšelj¹,

Miklavčič²

2008

Radiology and Oncology

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Section: Numerical Models -The Electroporation Processmentioning

confidence: 99%

Numerical modeling in electroporation-based biomedical applications

Pavšelj¹,

Miklavčič²

2008

Radiology and Oncology

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“…The results are indicated for two values of voltage, which correspond to the range of the voltage values previously measured with the fieldmeter device ( figure 5). In the literature, there are few papers describing skin dielectric constant, 1 r(skin) [31,32]. The values of skin relative permittivity are influenced by the humidity rate and skin hydration.…”

Section: ð4:7þmentioning

confidence: 99%

Interpretation of the human skin biotribological behaviour after tape stripping

Pailler-Mattéi

Guerret‐Piécourt

Zahouani

et al. 2011

J. R. Soc. Interface.

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The present study deals with the modification of the human skin biotribological behaviour after tape stripping. The tape-stripping procedure consists in the sequential application and removal of adhesive tapes on the skin surface in order to remove stratum corneum (SC) layers, which electrically charges the skin surface. The skin electric charges generated by tape stripping highly change the skin friction behaviour by increasing the adhesion component of the skin friction coefficient. It has been proposed to rewrite the friction adhesion component as the sum of two terms: the first classical adhesion term depending on the intrinsic shear strength, t 0 , and the second term depending on the electric shear strength, t elec . The experimental results allowed to estimate a numerical value of the electric shear strength t elec . Moreover, a plan capacitor model with a dielectric material inside was used to modelize the experimental system. This physical model permitted to evaluate the friction electric force and the electric shear strength values to calculate the skin friction coefficient after the tape stripping. The comparison between the experimental and the theoretical value of the skin friction coefficient after the tape stripping has shown the importance of the electric charges on skin biotribological behaviour. The static electric charges produced by tape stripping on the skin surface are probably able to highly modify the interaction of formulations with the skin surface and their spreading properties. This phenomenon, generally overlooked, should be taken into consideration as it could be involved in alteration of drug absorption.

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“…Skin, for example, is a very intricate tissue due to its highly inhomogeneous structure, leading to inhomogeneous electric properties. It consists of different layers, in terms of dimensions (thickness) and electrical properties: the outer thin layer of dead flat skin cells, the stratum corneum, the viable epidermis, dermis, and the subcutaneous tissue (Chizmadzhev et al, 1998;Yamamoto and Yamamoto, 1976;Yamamoto and Yamamoto, 1976a). If the aim of the model is to study electroporation of skin as a target tissue, this layered structure needs to be included in our geometrical representation (Pavselj et al, 2007).…”

Section: Biological Tissuesmentioning

confidence: 99%