“…Also, it is clear that the selectivity of streptavidin (κ = 2.1) toward keratin (κ = 10), gelatin (κ = 12), and other proteins (κ = 24) is 1.05 × 10 5 , 2.35 × 10 5 and 1.52 × 10 6 which is 3, 6, and 39 times greater than the published literature. 29 A comparison of the selectivities of the proposed SG-DC-VTFET biosensor for various biomolecules with respect to reference is characterized in Fig. 11d.…”
Section: Resultsmentioning
confidence: 99%
“…In this article, a novel split-gate double-cavity vertical tunnel field-effect transistor (SG-DC-VTFET) biosensor that exhibits exceptional selectivity and sensitivity, enabling effective detection of the COVID-19 pandemic, is developed. The impact of different biomolecules (charged or uncharged) on various parameters, 29 including energy band, electric field, I DS , transconductance, and surface potential, is examined. The sensitivities corresponding to I DS , transconductance, electric field, and surface potential are also investigated.…”
Section: Discussionmentioning
confidence: 99%
“…Selectivity of SG-DC-VTFET biosensor for (a) keratin (κ = 10) (b) gelatin (κ = 12) and (c) other proteins (κ = 24) toward other biomolecules (d) comparison of selectivity w.r.t. published literature 29.…”
The World Health Organization (WHO) has officially declared the international outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), often known as Coronavirus Disease 2019 (COVID-19), a global pandemic based on the significant and sudden increase in human infections worldwide. With suitable treatment and early diagnosis, this outbreak can be controlled to a certain extent. In the present research, the performance of a novel dielectrically-modulated heterojunction-based split gate double cavity vertical thin field-effect transistor (TFET) biosensor for detecting SARS-CoV-2 with reference to the virus’ spike, DNA, and envelope proteins has been thoroughly investigated. The suggested sensor's sensitivity has been evaluated through the computation of the deviation in drain current. We model the hybridized biomolecules in the nanogaps as the dielectric constant equivalent of the viral proteins. Additionally, sensing speed and selectivity analysis pertaining to the various biomolecules are also investigated. The proposed sensor exhibits a notably high sensitivity (on the order of 108), high sensing speed, and high selectivity (on the order of 106), indicating its potential as a superior sensor. Ultimately, the proposed sensor is evaluated in comparison to its sensitivity and selectivity of a variety of FET-based biosensors previously documented in the literature.
“…Also, it is clear that the selectivity of streptavidin (κ = 2.1) toward keratin (κ = 10), gelatin (κ = 12), and other proteins (κ = 24) is 1.05 × 10 5 , 2.35 × 10 5 and 1.52 × 10 6 which is 3, 6, and 39 times greater than the published literature. 29 A comparison of the selectivities of the proposed SG-DC-VTFET biosensor for various biomolecules with respect to reference is characterized in Fig. 11d.…”
Section: Resultsmentioning
confidence: 99%
“…In this article, a novel split-gate double-cavity vertical tunnel field-effect transistor (SG-DC-VTFET) biosensor that exhibits exceptional selectivity and sensitivity, enabling effective detection of the COVID-19 pandemic, is developed. The impact of different biomolecules (charged or uncharged) on various parameters, 29 including energy band, electric field, I DS , transconductance, and surface potential, is examined. The sensitivities corresponding to I DS , transconductance, electric field, and surface potential are also investigated.…”
Section: Discussionmentioning
confidence: 99%
“…Selectivity of SG-DC-VTFET biosensor for (a) keratin (κ = 10) (b) gelatin (κ = 12) and (c) other proteins (κ = 24) toward other biomolecules (d) comparison of selectivity w.r.t. published literature 29.…”
The World Health Organization (WHO) has officially declared the international outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), often known as Coronavirus Disease 2019 (COVID-19), a global pandemic based on the significant and sudden increase in human infections worldwide. With suitable treatment and early diagnosis, this outbreak can be controlled to a certain extent. In the present research, the performance of a novel dielectrically-modulated heterojunction-based split gate double cavity vertical thin field-effect transistor (TFET) biosensor for detecting SARS-CoV-2 with reference to the virus’ spike, DNA, and envelope proteins has been thoroughly investigated. The suggested sensor's sensitivity has been evaluated through the computation of the deviation in drain current. We model the hybridized biomolecules in the nanogaps as the dielectric constant equivalent of the viral proteins. Additionally, sensing speed and selectivity analysis pertaining to the various biomolecules are also investigated. The proposed sensor exhibits a notably high sensitivity (on the order of 108), high sensing speed, and high selectivity (on the order of 106), indicating its potential as a superior sensor. Ultimately, the proposed sensor is evaluated in comparison to its sensitivity and selectivity of a variety of FET-based biosensors previously documented in the literature.
“…Low I on values of 10 –17 to 10 –18 A are observed for the proposed GE-HTFET biosensor with air-filled nano-gap [ 13 , 24 ]. For such FET-based biosensors, the signal-to-noise ratio (SNR) would be limited during practical applications [ 25 ]. Fig.…”
In this article, the authors have articulated DC as well as transient response of a dielectric modulated gate-engineered heterostructure tunnel field effect transistor (GE-HTFET)-based biosensor for label-free detection. A low (direct) bandgap material, indium arsenide (InAs) has been selectively used in the source region to achieve improved band-to-band tunneling of carriers in the tunnel FET. The extended gate architecture is incorporated to stabilize the biomolecules in the nano-cavity aiding significant boost in ON current sensitivity. Using SILVACO ATLAS TCAD tool, the sensitivity of the biosensor is evaluated considering two important parameters possessed by bio-targets, i.e. dielectric constant (
k
) and charge density (
N
). A thorough analysis has been performed to show the impact of variation of dielectric constants and charge density of biomolecules over transfer characteristics of the device. ON current level (Ion) is eventually extracted which is considered here as the suitable sensing parameter of the device. Transient response to detect the settling time of Ion is also demonstrated here in presence of both positively and negatively charged bio-species with varying values of dielectric constant. Then ON current sensitivity is extracted accordingly for different locations of biomolecules within the nano-gap. Finally, an extensive comparative analysis of the present structure in terms of ON current sensitivity is shown to justify its sensing ability as compared to recently reported device structures.
“…The other devices like GAA-NWTFET, DGHG-FET, FinFET, Nanotube, TFET etc. [1][2][3][4][5][6][7][8] are recommended to minimize the SCEs and discover different way to examine lower off-current (I OFF ), power and reduced subthreshold-slope (SS) less than 60 mV/decade. From all the previous reported FETs based devices, TFET shows the required low SS and I OFF which is mostly preferred.…”
This work is based on the analysis and designing of gate all around N+-doped layer nanowire tunnel field-effect transistors (NTFET) without junctions for application in a biosensor by considering the various bio molecules like uricase, proteins, biotin, streptavidin, Aminopropyl-triethoxy-silane (ATS), and many more with dielectric modulation technique and gate-all-around (GAA) environment. Device sensitivity and tunneling probability is further improved by N+ doped layer (1×1020cm-3). The change in the subthreshold-slope (SS), drain current (ID), transconductance(gm), and ratio of ION/IOFF has been examined to detect the sensitivity of the proposed device by confining various biomolecules in the area of nanocavity. The nanocavity area creates a shield in the source gate of oxide layer and electrodes metal. The junctionless GAA-NTFET (JLGAA-NTFET) shows less leakage current and large control on the channel. The design of JLGAA-NTFET is with high doping concentration and observed higher sensitivity for APTS biomolecule which is suitable for sensor design application.
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