Dielectric nanohole array metasurface for high-resolution near-field sensing and imaging

Conteduca, Donato; Barth, Isabel; Pitruzzello, Giampaolo; Reardon, Christopher; Martins, Emiliano R.; Krauss, Thomas F.

doi:10.1038/s41467-021-23357-9

Cited by 113 publications

(99 citation statements)

References 46 publications

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“…This allows having a large area but still exploiting the advantages of near-field optics, in particular in terms of strong resolution. This approach has been experimentally validated in the literature with simple and feasible systems [42]. This behavior is also useful to obtain additional information about the first stage of the bacteria infection, when the bacteria cells enrich before they start to interact with each other to form the biofilm.…”

Section: Dual Array Of Interdigitated Electrodes: Architecture and Operationmentioning

confidence: 97%

“…Under this condition, the monitoring of the chemical and biological The structure exploiting the GMR effect has been designed to obtain a resonance condition for λ > 800 nm, where the absorption losses of silicon decrease [41], with the aim of achieving a higher extinction ratio and higher Q-factor, together with a strong energy confinement close to the surface to enhance the light interaction with the bacteria. The strong refractive index contrast between silicon and the surrounding medium allows a high confinement of the electromagnetic field at the sensor surface, enabling the use of the INEs section for hyperspectral imaging technique, as described in detail in [42], which allows the refractive index imaging, thus localizing objects on the grating by detecting the spatial resonance distribution. An inverted microscope configuration can be used to characterize the sensor, with the light source illuminating from the top and the reflected signal collected from the same side of the setup by a conventional CMOS camera.…”

Section: Dual Array Of Interdigitated Electrodes: Architecture and Operationmentioning

confidence: 99%

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Novel Micro-Nano Optoelectronic Biosensor for Label-Free Real-Time Biofilm Monitoring

et al. 2021

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According to the World Health Organization forecasts, AntiMicrobial Resistance (AMR) is expected to become one of the leading causes of death worldwide in the following decades. The rising danger of AMR is caused by the overuse of antibiotics, which are becoming ineffective against many pathogens, particularly in the presence of bacterial biofilms. In this context, non-destructive label-free techniques for the real-time study of the biofilm generation and maturation, together with the analysis of the efficiency of antibiotics, are in high demand. Here, we propose the design of a novel optoelectronic device based on a dual array of interdigitated micro- and nanoelectrodes in parallel, aiming at monitoring the bacterial biofilm evolution by using optical and electrical measurements. The optical response given by the nanostructure, based on the Guided Mode Resonance effect with a Q-factor of about 400 and normalized resonance amplitude of about 0.8, allows high spatial resolution for the analysis of the interaction between planktonic bacteria distributed in small colonies and their role in the biofilm generation, calculating a resonance wavelength shift variation of 0.9 nm in the presence of bacteria on the surface, while the electrical response with both micro- and nanoelectrodes is necessary for the study of the metabolic state of the bacteria to reveal the efficacy of antibiotics for the destruction of the biofilm, measuring a current change of 330 nA when a 15 µm thick biofilm is destroyed with respect to the absence of biofilm.

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Section: Dual Array Of Interdigitated Electrodes: Architecture and Operationmentioning

confidence: 97%

Section: Dual Array Of Interdigitated Electrodes: Architecture and Operationmentioning

confidence: 99%

Novel Micro-Nano Optoelectronic Biosensor for Label-Free Real-Time Biofilm Monitoring

et al. 2021

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“…More recently, Conteduca et al demonstrated a dielectric nanohole array (Figure 4c) in amorphous silicon (a:Si) that supports two optical modes, both with relatively moderate Q-factors (300-400) and submicron spatial resolution, desirable for both imaging and biochemical sensing [68]. They demonstrated IgG sensing with a limit of detection (LOD) lower than 1 pg/mL using a TM mode with high Q-factor and high surface sensitivity, while the high resonance amplitude and strong confinement of the TE mode enables a spatial resolution below 1 μm that clearly resolves features of individual E. coli bacteria (Figure 4d).…”

Section: Metamaterial-enhanced Refractometric Microscopymentioning

confidence: 99%

Microscopies Enabled by Photonic Metamaterials

Xiong

Che

et al. 2022

Sensors

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In recent years, the biosensor research community has made rapid progress in the development of nanostructured materials capable of amplifying the interaction between light and biological matter. A common objective is to concentrate the electromagnetic energy associated with light into nanometer-scale volumes that, in many cases, can extend below the conventional Abbé diffraction limit. Dating back to the first application of surface plasmon resonance (SPR) for label-free detection of biomolecular interactions, resonant optical structures, including waveguides, ring resonators, and photonic crystals, have proven to be effective conduits for a wide range of optical enhancement effects that include enhanced excitation of photon emitters (such as quantum dots, organic dyes, and fluorescent proteins), enhanced extraction from photon emitters, enhanced optical absorption, and enhanced optical scattering (such as from Raman-scatterers and nanoparticles). The application of photonic metamaterials as a means for enhancing contrast in microscopy is a recent technological development. Through their ability to generate surface-localized and resonantly enhanced electromagnetic fields, photonic metamaterials are an effective surface for magnifying absorption, photon emission, and scattering associated with biological materials while an imaging system records spatial and temporal patterns. By replacing the conventional glass microscope slide with a photonic metamaterial, new forms of contrast and enhanced signal-to-noise are obtained for applications that include cancer diagnostics, infectious disease diagnostics, cell membrane imaging, biomolecular interaction analysis, and drug discovery. This paper will review the current state of the art in which photonic metamaterial surfaces are utilized in the context of microscopy.

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“…Fano resonances brought by symmetry-breaking structures like nanocubes on substrate [12], gold nano-disks integrated with indium tin oxide (ITO) [22], plasmonic nanoantenna on a graphene sheet [23], nanodisk surrounded by gold nanorods with different orientations [24], etc. often has high sensitivity to surrounding environment [25][26][27]. LSPR brought by different metal nanostructures i.e., nanoparticles [28], nanorods [29], nanostars [30] is also utilized in optical sensing for its ability of wavelength shift with the change of the surrounding [31] and enhancing scattering [32].…”

Section: Introductionmentioning

confidence: 99%

Numerical Investigation of Multifunctional Plasmonic Micro-Fiber Based on Fano Resonances and LSPR Excited via Cylindrical Vector Beam

Liu

Lei

et al. 2021

Sensors

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Function expansion of fiber sensor is highly desired for ultrasensitive optical detection and analysis. Here, we present an approach of multifunctional fiber sensor based on Fano resonances and localized surface plasmon resonance (LSPR) excited via cylindrical vector beam with ability of refractive index (RI) sensing, nano-distance detection, and surface enhanced Raman spectroscopy (SERS). Silver (Ag)-nanocube modified microfiber is theoretically proved to enable to detect RI of the nearby solids and gases based on Fano resonances with a sensitivity of 128.63 nm/refractive index unit (RIU) and 148.21 nm/RIU for solids and gases, respectively. The scattering spectrum of the Ag nanocube has the red-shift response to the varies of the nano-distance between the nanocube and the nearby solid, providing a detection sensitivity up to 1.48 nm (wavelength)/nm (distance). Moreover, this configuration is theoretically verified to have ability to significantly enhance electric field intensity. Radially polarized beam is proved to enhance the electric field intensity as large as 5 times in the side-face configuration compared with linear polarization beam. This fiber-based sensing method is helpful in fields of remote detection, multiple species detection, and cylindrical vector beam-based detection.

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Dielectric nanohole array metasurface for high-resolution near-field sensing and imaging

Cited by 113 publications

References 46 publications

Novel Micro-Nano Optoelectronic Biosensor for Label-Free Real-Time Biofilm Monitoring

Novel Micro-Nano Optoelectronic Biosensor for Label-Free Real-Time Biofilm Monitoring

Microscopies Enabled by Photonic Metamaterials

Numerical Investigation of Multifunctional Plasmonic Micro-Fiber Based on Fano Resonances and LSPR Excited via Cylindrical Vector Beam

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