Dielectric phenomena associated with the keratin–glucose interactions of nail plate

Marzec, E.; Wierzbicki, K.; Olszewski, Jan; Samborski, Włodzimierz; Skorupska, Elżbieta; Bahloul, K.; Krzywicka, A.; Krauss, Hanna

doi:10.1016/j.colsurfb.2013.03.032

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…However, the revealed increase appears to be correlated with the glucose concentration in the incubation medium. This finding is particularly interest because some recent studies show that some keratins can form complexes with glucose . In conclusion, our body of evidence demonstrates that the presence of glucose in human plasma has an effect on the interactions between liposomes and plasma proteins and this effect causes variations in the composition of the BC.…”

Section: Discussionmentioning

confidence: 61%

“…This finding is particularly interest because some recent studies show that some keratins can form complexes with glucose. [35] In conclusion, our body of evidence demonstrates that the presence of glucose in human plasma has an effect on the interactions between liposomes and plasma proteins and this effect causes variations in the composition of the BC. In addition, when Doxoves-HP and Onivyde-HP complexes are formed in the presence of glucose, they are significantly more cytotoxic than their counterparts shaped in the absence of glucose.…”

Section: Discussionmentioning

confidence: 85%

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Effect of Glucose on Liposome–Plasma Protein Interactions: Relevance for the Physiological Response of Clinically Approved Liposomal Formulations

et al. 2018

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Recently, the concept is emerging that the reduced success of nanoparticles in clinical practice is due to the adsorption of the “biomolecular corona (BC),” which alters their biological identity. Apart from protein variations, alterations in the human metabolome may change the BC decoration, which has poorly been addressed so far. Here, glucose is used as a model metabolite and how the interactions between liposomes (as a model nanoparticle) and plasma proteins are influenced by normal and diabetic sugar blood levels is explored. As model liposomes, Doxoves and Onivyde are used that are used for the treatment of breast and metastatic pancreatic cancer, respectively. It is shown that glucose does affect the structure and composition of BC. The biological effects of liposome–BC complexes are investigated in MCF 7 and MDA‐MB‐231 breast cancer cells for Doxoves and in pancreatic adenocarcinoma (PANC‐1) and insulinoma (INS‐1) cells for Onivyde. In the presence of glucose, the cellular toxicity of liposome–protein complexes and uptake by human monocytic THP1 cell line increases. These results demonstrate that alterations in glucose concentration, and more generally changes in the human metabolome, may play a fundamental role in the biological identity of liposomes and, consequently, on their in vivo physiological readouts including therapeutic efficacy.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 85%

Effect of Glucose on Liposome–Plasma Protein Interactions: Relevance for the Physiological Response of Clinically Approved Liposomal Formulations

et al. 2018

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“…The curves for dry nail do not contain these peaks due to the lack of loosely bound water in this sample. Our previous dielectric studies of the human nail with about 11% water [4][5][6][7] also revealed the process of removing water, but at a lower temperature of 80°C. Release of water in other a-keratin fibers using the DSC method [14][15][16][17] was also observed in a similar temperature range.…”

Section: Methodsmentioning

confidence: 90%

“…The influence of such external factors as relative humidity, temperature and electromagnetic radiation on the nail causes a physical-chemical release of the matrix-keratinwater composite forming this tissue. The results of our previous dielectric studies of the nail [4][5][6][7] indicate the key role of water in protecting the ordered crystalline structure of the keratin molecule before the onset of the melting process. In recent years, nails research also deals with the influence of water on the biophysical and chemical structure of this material [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 92%

Influence of water and temperature on the electrical conductivity of the human nail

Marzec

Olszewski

2019

J Therm Anal Calorim

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The human toenail was measured in vitro in the alpha-dispersion region of the electric field and the temperature from 22 to 150°C. The values of dielectric properties are much higher in the wet nails than in those without water of the same temperature and frequency. The peak temperature of dielectric parameters near 100°C for wet nails is attributed to the water removal process. The dielectric spectra of the nail revealed high-frequency relaxation at 25 kHz irrespective of the water content in the tissue. Our dielectric studies of the nail plate enable deeper analysis of the matrix-keratin-water system, which can facilitate the assessment of the electrical conductivity of this tissue in the state of health and diseased.

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Dielectric properties of healthy and diabetic alloxan-induced lenses in rabbits

Marzec

Rossi

Paolucci

et al. 2020

Bioelectrochemistry

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Dielectric phenomena associated with the keratin–glucose interactions of nail plate

Cited by 3 publications

References 21 publications

Effect of Glucose on Liposome–Plasma Protein Interactions: Relevance for the Physiological Response of Clinically Approved Liposomal Formulations

Effect of Glucose on Liposome–Plasma Protein Interactions: Relevance for the Physiological Response of Clinically Approved Liposomal Formulations

Influence of water and temperature on the electrical conductivity of the human nail

Dielectric properties of healthy and diabetic alloxan-induced lenses in rabbits

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