Dielectric Properties of the Human Red Blood Cell

Генералов, В. М.; Сафатов, А. С.; Кручинина, М. В.; Gromov, Andrey; Buryak, G. A.; Генералов, К. В.; Кручинин, В. Н.

doi:10.1007/s11018-020-01826-9

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…This phenomenon is related to the relative dielectric constant of the cytoplasm. The main component of the cytoplasm is water, which can be regarded as a polar fluid, and most of its losses are polarized losses ( Generalov et al, 2020 ). As the terahertz frequency increases, the cytoplasm’s polarization loss attenuates and the neuron’s internal field strength and temperature increase.…”

Section: Discussionmentioning

confidence: 99%

The laws and effects of terahertz wave interactions with neurons

Gong

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: Terahertz waves lie within the energy range of hydrogen bonding and van der Waals forces. They can couple directly with proteins to excite non-linear resonance effects in proteins, and thus affect the structure of neurons. However, it remains unclear which terahertz radiation protocols modulate the structure of neurons. Furthermore, guidelines and methods for selecting terahertz radiation parameters are lacking.Methods: In this study, the propagation and thermal effects of 0.3–3 THz wave interactions with neurons were modelled, and the field strength and temperature variations were used as evaluation criteria. On this basis, we experimentally investigated the effects of cumulative radiation from terahertz waves on neuron structure. Results: The results show that the frequency and power of terahertz waves are the main factors influencing field strength and temperature in neurons, and that there is a positive correlation between them. Appropriate reductions in radiation power can mitigate the rise in temperature in the neurons, and can also be used in the form of pulsed waves, limiting the duration of a single radiation to the millisecond level. Short bursts of cumulative radiation can also be used. Broadband trace terahertz (0.1–2 THz, maximum radiated power 100 μW) with short duration cumulative radiation (3 min/day, 3 days) does not cause neuronal death. This radiation protocol can also promote the growth of neuronal cytosomes and protrusions.Discussion: This paper provides guidelines and methods for terahertz radiation parameter selection in the study of terahertz neurobiological effects. Additionally, it verifies that the short-duration cumulative radiation can modulate the structure of neurons.

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Section: Discussionmentioning

confidence: 99%

The laws and effects of terahertz wave interactions with neurons

Gong

et al. 2023

Front. Bioeng. Biotechnol.

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“…In summary, the frequency of terahertz radiation is also an important factor affecting neurons by the mechanism of absorption and resonance of terahertz radiation by neurons. Since both the neuron size and the terahertz wavelength are on the order of micrometers, they are equipped to interact [ 78 , 79 , 80 ]. In addition, the resonance peaks between biological macromolecules are different, so there are differences in the effects of different frequencies of terahertz radiation on neurons.…”

Section: The Impact Of Terahertz Radiation On Neuronal Morphology And...mentioning

confidence: 99%

Terahertz Radiation Modulates Neuronal Morphology and Dynamics Properties

Ma,

Ding,

Zhou

et al. 2024

Brain Sciences

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Terahertz radiation falls within the spectrum of hydrogen bonding, molecular rotation, and vibration, as well as van der Waals forces, indicating that many biological macromolecules exhibit a strong absorption and resonance in this frequency band. Research has shown that the terahertz radiation of specific frequencies and energies can mediate changes in cellular morphology and function by exciting nonlinear resonance effects in proteins. However, current studies have mainly focused on the cellular level and lack systematic studies on multiple levels. Moreover, the mechanism and law of interaction between terahertz radiation and neurons are still unclear. Therefore, this paper analyzes the mechanisms by which terahertz radiation modulates the nervous system, and it analyzes and discusses the methods by which terahertz radiation modulates neurons. In addition, this paper reviews the laws of terahertz radiation’s influence on neuronal morphology and kinetic properties and discusses them in detail in terms of terahertz radiation frequency, energy, and time. In the future, the safety of the terahertz radiation system should be considered first to construct the safety criterion of terahertz modulation, and the spatial resolution of the terahertz radiation system should be improved. In addition, the systematic improvement of the laws and mechanisms of terahertz modulation of the nervous system on multiple levels is the key to applying terahertz waves to neuroscience. This paper can provide a platform for researchers to understand the mechanism of the terahertz–nervous system interaction, its current status, and future research directions.

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“…However, cellular self-regulation and likely homeostasis maintain the relatively stable dielectric properties of erythrocytes [ 208 ]. This fact reflects the importance of these parameters as promising candidates for diagnostic purposes [ 209 ]. In addition to conventional techniques, including electrorotation (ROT) [ 210 – 212 ], impedance spectroscopy [ 202 ], and dielectrophoresis (DEP) [ 199 ], custom-designed microfluidic methods have been used to measure the dielectric properties of cells even at single-cell resolution [ 213 , 214 ].…”

Section: Introductionmentioning

confidence: 99%

Biomechanics of circulating cellular and subcellular bioparticles: beyond separation

Aghajanloo,

Hadady,

Ejeian

et al. 2024

Cell Commun Signal

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Biomechanical attributes have emerged as novel markers, providing a reliable means to characterize cellular and subcellular fractions. Numerous studies have identified correlations between these factors and patients’ medical status. However, the absence of a thorough overview impedes their applicability in contemporary state-of-the-art therapeutic strategies. In this context, we provide a comprehensive analysis of the dimensions, configuration, rigidity, density, and electrical characteristics of normal and abnormal circulating cells. Subsequently, the discussion broadens to encompass subcellular bioparticles, such as extracellular vesicles (EVs) enriched either from blood cells or other tissues. Notably, cell sizes vary significantly, from 2 μm for platelets to 25 μm for circulating tumor cells (CTCs), enabling the development of size-based separation techniques, such as microfiltration, for specific diagnostic and therapeutic applications. Although cellular density is relatively constant among different circulating bioparticles, it allows for reliable density gradient centrifugation to isolate cells without altering their native state. Additionally, variations in EV surface charges (-6.3 to -45 mV) offer opportunities for electrophoretic and electrostatic separation methods. The distinctive mechanical properties of abnormal cells, compared to their normal counterparts, present an exceptional opportunity for diverse medical and biotechnological approaches. This review also aims to provide a holistic view of the current understanding of popular techniques in this domain that transcend conventional boundaries, focusing on early harvesting of malignant cells from body fluids, designing effective therapeutic options, cell targeting, and resonating with tissue and genetic engineering principles. Graphical Abstract This review provides a comprehensive and clear overview of the size/shape, stiffness, density, and electrical properties of circulating cellular/noncellular

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Dielectric Properties of the Human Red Blood Cell

Cited by 5 publications

References 14 publications

The laws and effects of terahertz wave interactions with neurons

The laws and effects of terahertz wave interactions with neurons

Terahertz Radiation Modulates Neuronal Morphology and Dynamics Properties

Biomechanics of circulating cellular and subcellular bioparticles: beyond separation

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