Dielectric response of human melanoma cells on the surface of polymeric chemoattractants

Abstract

The influences of dielectric properties on the malignant cell adhesion and migration have been investigated. The Wistar Melanomas, primary (WM793) and metastatic (WM1205), respectively, were chosen as the model cell lines because of their pleomorphic and invasive characteristics, and the dielectric relaxation frequencies of the cells were determined using the impedance spectroscopy. Both WM793 and WM1205 showed the enhanced adhesion and the interesting changes in their morphology under the dielectric stimulations. However, it was found that the changed conditions of cell adhesion due to dielectric relaxation did not influence the migrational behavior of the cells.