Dielectrophoretic Microfluidic Chip Integrated With Liquid Metal Electrode for Red Blood Cell Stretching Manipulation

Zhu, Botao; Cai, Yifan; Wu, Zhengtian; Niu, Fuzhou; Yang, Hao

doi:10.1109/access.2019.2948191

Cited by 16 publications

(12 citation statements)

References 42 publications

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“…In many experiments that use DEP to measure the cellular mechanical properties, precious metal electrodes, such as gold and platinum, require magnetron sputtering, which is complex and expensive. Indium tin oxide (ITO) electrodes have low cost and are simple to manufacture and thus widely used in measuring the mechanical properties of cells, such as red blood cells and NB 4 [12][13][14]. However, the majority of previous studies only performed a unidirectional measurement of the cellular mechanical properties and therefore resulted in incomprehensive measured data.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Dielectrophoresis‐Based Method for Measuring the Multiangle Mechanical Properties of Biological Cells

Zhu

et al. 2020

BioMed Research International

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The mechanical properties of cells are closely related to their physiological functions and states. Analyzing and measuring these properties are beneficial to understanding cell mechanisms. However, most measurement methods only involve the unidirectional analysis of cellular mechanical properties and thus result in the incomplete measurement of these properties. In this study, a microfluidic platform was established, and an innovative microfluidic chip was designed to measure the multiangle cellular mechanical properties by using dielectrophoresis (DEP) force. Three unsymmetrical indium tin oxide (ITO) microelectrodes were designed and combined with the microfluidic chip, which were utilized to generate DEP force and stretch cell from different angles. A series of experiments was performed to measure and analyze the multiangle mechanical properties of red blood cells of mice. This work provided a new tool for the comprehensive and accurate measurement of multiangle cellular mechanical properties. The results may contribute to the exploration of the internal physiological structures of cells and the building of accurate cell models.

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Section: Introductionmentioning

confidence: 99%

[Retracted] Dielectrophoresis‐Based Method for Measuring the Multiangle Mechanical Properties of Biological Cells

Zhu

et al. 2020

BioMed Research International

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“…Among the substances involved in the color reaction, the molecular size of AChE is the largest, while the diffusion coefficient is the smallest, so the purpose of microchip channel design is to realize the rapid and complete mixing of AChE. The length, width and height of AChE were 98 nm, 79 nm and 3 nm, respectively [ 28 ]. The physical parameters of the mixed liquid are shown in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

Development of Rapid and High-Precision Colorimetric Device for Organophosphorus Pesticide Detection Based on Microfluidic Mixer Chip

et al. 2021

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The excessive pesticide residues in cereals, fruit and vegetables is a big threat to human health, and it is necessary to develop a portable, low-cost and high-precision pesticide residue detection scheme to replace the large-scale laboratory testing equipment for rapid detection of pesticide residues. In this study, a colorimetric device for rapid detection of organophosphorus pesticide residues with high precision based on a microfluidic mixer chip was proposed. The microchannel structure with high mixing efficiency was determined by fluid dynamics simulation, while the corresponding microfluidic mixer chip was designed. The microfluidic mixer chip was prepared by a self-developed liquid crystal display (LCD) mask photo-curing machine. The influence of printing parameters on the accuracy of the prepared chip was investigated. The light source with the optimal wavelength of the device was determined by absorption spectrum measurement, and the relationship between the liquid reservoir depth and detection limit was studied by experiments. The correspondence between pesticide concentration and induced voltage was derived. The minimum detection concentration of the device could reach 0.045 mg·L−1 and the average detection time was reduced to 60 s. The results provide a theoretical and experimental basis for portable and high-precision detection of pesticide residues.

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“…[135] Similarly, metallic alloys that are liquid at low (ambient or close to ambient) temperatures, including eutectic mixtures, are an interesting new class of biomaterials with a wide range of applications. [136,137] These metals have been used in a variety of microfluidic systems, [138] including in wearable devices for realtime pulse and movement monitoring [139] and as electrodes for in vitro neural stimulation. [140] Microfluidic methods have been used to fabricate structures, such as reconfigurable antennae, from such metals for use off-chip.…”

Section: New Directions For Production Of Biomaterials On Chipmentioning

confidence: 99%

Chips for Biomaterials and Biomaterials for Chips: Recent Advances at the Interface between Microfabrication and Biomaterials Research

Guttenplan

Birgani

Giselbrecht

et al. 2021

Adv Healthcare Materials

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In recent years, the use of microfabrication techniques has allowed biomaterials studies which were originally carried out at larger length scales to be miniaturized as so-called "on-chip" experiments. These miniaturized experiments have a range of advantages which have led to an increase in their popularity. A range of biomaterial shapes and compositions are synthesized or manufactured on chip. Moreover, chips are developed to investigate specific aspects of interactions between biomaterials and biological systems. Finally, biomaterials are used in microfabricated devices to replicate the physiological microenvironment in studies using so-called "organ-on-chip," "tissue-on-chip" or "disease-on-chip" models, which can reduce the use of animal models with their inherent high cost and ethical issues, and due to the possible use of human cells can increase the translation of research from lab to clinic. This review gives an overview of recent developments at the interface between microfabrication and biomaterials science, and indicates potential future directions that the field may take. In particular, a trend toward increased scale and automation is apparent, allowing both industrial production of micron-scale biomaterials and high-throughput screening of the interaction of diverse materials libraries with cells and bioengineered tissues and organs.

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Dielectrophoretic Microfluidic Chip Integrated With Liquid Metal Electrode for Red Blood Cell Stretching Manipulation

Cited by 16 publications

References 42 publications

[Retracted] Dielectrophoresis‐Based Method for Measuring the Multiangle Mechanical Properties of Biological Cells

[Retracted] Dielectrophoresis‐Based Method for Measuring the Multiangle Mechanical Properties of Biological Cells

Development of Rapid and High-Precision Colorimetric Device for Organophosphorus Pesticide Detection Based on Microfluidic Mixer Chip

Chips for Biomaterials and Biomaterials for Chips: Recent Advances at the Interface between Microfabrication and Biomaterials Research

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